Scientific AVP, Clinical Research, Oncology Early Development

We are searching for a Section Lead to join Oncology Early Development (OED). This opportunity will oversee clinical strategy for one third of our company’s early development internal pipeline, partner with cross‑functional subject matter experts, and drive oncology assets from preclinical to clinical proof‑of‑concept milestones.

• Strategic Leadership – Oversee development of an array of early pipeline assets including IO targets, ADCs, TCEs and small molecules; mentor reports; represent programs in senior management and governance forums; conduct safety assessment for Phase 1 designs, characterize biomarkers and conduct dose‑finding for new compounds; evaluate new compound opportunities for BD/acquisitions.
• Clinical Development Plan (CDP) – Develop and execute end‑to‑end clinical plans, including Phase 1/2 trial design, IND submissions and Investigator Brochures.
• Cross‑functional Collaboration – Partner with Discovery, Translational Medicine, Clinical Pharmacology, Regulatory and Operations teams to ensure fast and effective trial execution.
• Scientific & Medical Expertise – Analyze patient data, including PK/PD modeling and biomarkers to optimize dosing and compound strategy.
• Talent Management – Mentor and provide feedback to clinical team members and scientists; build high‑performing teams.
• External Outreach & Leadership – Stay abreast of professional information, industry trends and emerging technology; maintain a comprehensive understanding of the competitive environment and assess potential impact on ongoing programs.

• MD, MD/PhD, with a strong background in oncology and early drug development.

• 10+ years of industry experience, with at least 5 years in oncology early development.
• In‑depth knowledge of Phase 1 clinical trial methodology, regulatory and compliance requirements governing clinical trials, and experience in developing clinical strategy and study protocols.
• Strong scientific background in oncology drug development (basic, translational and/or clinical); experience with multiple mechanisms of action (small molecules, biologics including ADCs and TCEs); experience in designing and conducting oncology early clinical trials.
• Proven leadership skills and ability to bring out the best in others on a cross‑functional global team.
• Ability to lead and manage through influence, delegate accountability and decision‑making to support teams.
• Strong collaboration, facilitative leadership, executive function and problem‑solving skills.
• Ability to respectfully challenge team members and functions in order to assess fully all opportunities, options, risks and mitigations.
• Demonstrated commitment to training and development of junior‑level staff, using best judgment to ensure appropriate autonomy.
• Ability to interact externally and internally to support a global scientific and business strategy.
• Ability to oversee multiple complex clinical research programs.
• Excellent oral and written communication skills.

• Change Management, Clinical Pharmacology, Clinical Strategy, Clinical Trial Development, Consulting, Ethical Standards, Executive Presence, Immunology, Innovation, Interpersonal Relationships, Ophthalmology, Professional Networking, Results‑Oriented, Translational Medicine, Vaccine Development.

We are an Equal Employment Opportunity Employer and provide equal opportunities to all employees and applicants for employment. We prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status or other applicable legally protected characteristics. We comply with all affirmative action requirements for protected veterans and individuals with disabilities.

San Francisco Residents Only:
We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.

Los Angeles Residents Only:
We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with applicable state and local laws.

Salary range: $ – $ per year. The employee’s position within the range will be based on multiple factors including relevant education, qualifications and experience.

Eligibility for annual bonus and long‑term incentive, if applicable.

Benefits include medical, dental, vision, healthcare insurance, retirement benefits including 401(k), paid holidays, vacation and compassionate and sick days. More information about benefits is available at the provided URL.

End Date: 07/27/2026

R405478