QA Investigations Lead II

Legend Biotech

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life‑threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T‑cell, T‑cell receptor (TCR‑T), and natural killer (NK) cell‑based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting‑edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta‑cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

We are seeking a QA Investigations Lead I as part of the Quality team based in Raritan, NJ.

The QA Investigation Lead is an exempt level position reporting to the QA Investigation Supervisor within the Raritan Investigation Excellence Team. The QA Investigation Lead is responsible for providing quality oversight and guidance during the investigation of events that occur in the production of a personalized cell therapy product in a sterile GMP environment. The ideal candidate for this role demonstrates a quality mindset to strive for excellence, continuous improvement and ethical conduct in attaining and maintaining the highest levels of quality.

• Ensure the timely completion of high‑quality robust investigations with appropriate root cause(s).
• Ensure appropriate Corrective and Preventative Actions (CAPA's) are developed and implemented.
• Escalate events to management that potentially represent significant quality issues or issues resulting in the delay of investigation closure and product release.
• Support regulatory inspections and audits by ensuring inspection readiness within facility and serving as an SME during the execution of regulatory inspections and audits as needed.
• Support compliance activities for site Quality Operations in accordance with Legend standards, procedures and cGMPs.
• Collaborate with site personnel to provide guidance and determine resolution for end‑to‑end manufacturing issues.
• Ensure accurate and timely maintenance and review of manufacturing investigations, CAPAs, change controls and complaints.
• Perform analysis on quality indicating data and identifying trends.
• Contribute to maintain investigation compliance metrics.
• Support investigation process improvement initiatives.
• Job duties performed may require exposure to and handling of biological materials and hazardous chemicals.
• Able to work independently and also in a collaborative team setting with quality counterparts that include Manufacturing Operations, Operations Technical Support, Maintenance, Supply Chain and Planning.

• A minimum of a Bachelor's Degree in Science, Engineering or equivalent technical discipline.
• A minimum of 2-4 years relevant work experience. Preferably in an aseptic manufacturing facility, in quality assurance, manufacturing compliance, clinical quality, or cell therapy.
• Knowledge of cGMP and GDP regulations and FDA/EU guidance related to manufacture of cell‑based products.
• Great attention to detail and ability to follow procedures.
• Highly organized with the ability to work in a team environment with a positive attitude under minimal supervision.
• Excellent organizational skills with the ability to simplify and clearly communicate complex concepts.
• Excellent verbal, written and presentation capabilities.
• Ability to summarize and present results; experience with team‑based collaborations is a must.
• Ability to interpret problems and determine appropriate resolutions that ensure compliance and minimize risk.
• Strong leadership skills and effective development of others.
• Ability to collaborate well with stakeholders, customers and peers.
• Strong decision‑making ability and creative thinking while…