Part-Time Senior Scientist – Cell Biology

Part-Time Senior Scientist - Cell Biology & In Vitro Assays

Aphios Corporation, a clinical-stage biotechnology company, is seeking an experienced PhD-level Scientist / Senior Scientist with strong hands-on expertise in mammalian cell culture and cell-based assay development
.

We are particularly interested in experienced biotechnology/pharmaceutical scientists seeking a flexible part-time or consulting role
, including senior scientists transitioning from full-time industry careers, as well as experienced academic research scientists in the Boston/Cambridge scientific community who would welcome the opportunity to contribute directly to therapeutic development.

This is not primarily a management position. We are looking for a scientist who still enjoys experimental design, hands-on laboratory work, troubleshooting, data interpretation, and scientific problem-solving at the bench
.

The scientist’s initial responsibility will be to establish, optimize, and conduct an in vitro anti-nausea assay using recombinant stomach-derived cells
, including:

• Establishing and maintaining recombinant cell cultures
• Adapting and optimizing assay protocols
• Designing appropriate experimental controls
• Conducting concentration- and dose-response studies
• Evaluating therapeutic candidates and formulations
• Assessing assay sensitivity, reproducibility, and variability
• Analyzing and interpreting experimental results
• Establishing standardized protocols and SOPs

Substantially in parallel, the scientist will contribute to in vitro research supporting Aphios’
GLP-1 and Alzheimer’s disease programs
, potentially including assays involving:

• Alpha-secretase activity
• Protein kinase C (PKC) activation and signaling
• Inflammatory and anti-inflammatory pathways
• Cytokine expression and release
• Cell viability and cytotoxicity
• Cellular signaling and mechanistic studies
• Dose-response evaluation of therapeutic candidates

• PhD in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, Neuroscience, Physiology, or a closely related discipline
• Strong hands-on mammalian cell-culture experience
• Demonstrated experience developing and conducting cell-based assays
• Experience with recombinant or engineered cell systems
• Ability to independently establish, optimize, and troubleshoot assays
• Strong experimental design, quantitative analysis, and scientific documentation skills
• Desire to remain actively involved in laboratory research

• Pharmaceutical or biotechnology R&D
• Gastrointestinal biology or nausea/emesis pharmacology
• GLP-1 biology or receptor signaling
• Alzheimer’s disease/neurodegeneration
• PKC and alpha-secretase biology
• Cytokine and inflammatory assays
• ELISA, immunoassays, Western blotting, fluorescence, luminescence, or reporter assays
• Cell viability and cytotoxicity testing

This position may be particularly attractive to a senior industry scientist seeking to remain scientifically active on a flexible basis
, or an experienced academic scientist interested in applying deep laboratory expertise directly to therapeutic development.

Rather than supervising a large research organization, the successful candidate will have the opportunity to personally establish important assays, generate and interpret data, and influence the scientific direction of multiple development programs
.

The position is structured as part-time / consulting
, with flexibility based on experience, availability, and program requirements.

Aphios is advancing a diversified therapeutic portfolio that includes a planned Phase III clinical program for Zindol®, planned Phase IIb programs in opioid addiction and chronic epilepsy
, and additional therapeutic programs progressing through IND-enabling development.