Senior IT Infrastructure Engineer

Overview

Syst Immune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). Syst Immune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, Syst Immune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development.

We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking a highly skilled Senior IT Infrastructure Engineer to join our growing organization. While we are not a startup, we are in an active growth phase, and this role requires someone who thrives in a dynamic, evolving environment. This is a hands-on, high-impact position where you will work closely with IT leadership to manage and scale a complex hybrid infrastructure spanning on-premises data centers and cloud environments.

You will play a critical role in maintaining stability while also driving improvements, standardization, and growth. We are looking for a self-driven, solution-oriented engineer who is comfortable wearing multiple hats, taking ownership of large initiatives, and operating at a senior technical level.

This role requires full-time onsite presence in our Redmond, WA office, with a planned relocation to our new Bothell, WA facility in fall 2026.

• Manage and support a hybrid infrastructure (on-prem + cloud)
• Administer Palo Alto firewalls, Cisco switches and routers, VMware and Hyper-V environments
• Design and troubleshoot network configurations including site-to-site VPNs and routing
• Oversee Microsoft 365 administration including licensing and user management
• Manage remote tools such as Datto RMM, Team Viewer, Go To Assist
• Support conference room systems (Logitech)
• Administer NAS/storage systems for hypervisors
• Work across Windows Server and Linux (Ubuntu, CentOS, Debian)
• Assist with SQL systems (preferred)
• Support Azure/cloud infrastructure (plus)
• Create documentation, SOPs, and diagrams
• Support users across multiple locations

• Bachelor's degree in Information Technology, Information Management Systems, Computer Science, or a related field required.
• Minimum of 5–8 years of hands-on IT infrastructure experience, including server administration, enterprise networking, and end-user support; prior experience in a senior or lead capacity is strongly preferred.

• Life Sciences environment experience
• Waters Empower, UNIFI, Connect
• Geneious Prime, Dotmatics Discovery Studio, Tableau
• Regulated environments (GxP, HIPAA)

• Strong network engineering expertise
• Independent troubleshooting ability
• Comfort in a fast-paced environment
• Proactive, go-getter mindset
• Ability to leverage AI/tools for research
• Strong documentation and communication skills
• Ownership and accountability

Primarily on-site with local travel. Supports distributed teams across the U.S. High-autonomy, collaborative environment.

The expected base salary range for this position is $100,000 - $135,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.

Syst Immune is a leading and well-funded biotech company with a bright future. We offer a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of 5 years, 15 PTO days per year, sick leave, 11 paid holidays, and more.

Syst Immune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.