Principal Scientist, Purification Process Design

Job Title:

Principal Scientist, Purification

Location:

Redmond, WA

Reports to:

Associate Director, Purification

• Lead a diverse group of scientists encompassing all aspects of purification process development, characterization, and validation as well as technology transfer to cGMP manufacturing for hybrid and continuous processes.
• Serve as an internal technical resource for cGMP manufacturing and Process Design as well as a subject‑matter expert for external clients and partners for purification processes (small‑scale models, process transfer, and scale‑up) and authoring CMC regulatory sections.
• Act as a functional area lead for platform or complex client early‑stage (FIH) and late‑stage Process Characterization (PC) projects as well as technology development projects.
• Collaborate across the organization to accelerate clinical development timelines while reducing development costs.
• Communicate scientific information, experimental plans, and data clearly to internal project teams, senior management, external clients, vendors, technology development collaborators and the external scientific community such as regulatory agencies, review boards, and conferences.
• Design, execute, and analyze statistically designed experiments (DOE) independently.
• Author SOPs, reports, and slides that summarize, organize, and interpret experiment results with appropriate review.
• Work with vendors and manufacturers in developing, ordering, and troubleshooting equipment prototypes.
• Train, mentor, and supervise staff and interns.
• Drive technology development for process intensification and continuous manufacturing to reduce manufacturing costs and footprint through improvements in culture productivity, product‑quality control, and data management.
• Support the management of staff, capital resources, and planning within the department.
• Perform other tasks as assigned.

• BS/MS in Engineering, Biochemistry, Biology, or related field with 12+ years of experience or a Ph.D. in Engineering, Biochemistry, Biology, or related field with 8+ years of experience.
• Expertise in purification technology and process development, transfer to cGMP manufacturing plants, and authoring CMC sections of regulatory filings.
• Experience with commercial process development, process characterization, and validation.
• Expertise in design of experiments (DOE) and statistical analysis.
• Experience in training, mentoring, and supervising team members, as well as leading development teams for external client projects, collaborations, and internal technology development initiatives.
• Experience with high‑throughput process development systems is a plus.
• Experience analyzing data in tools such as JMP, R, or Python.
• General understanding of cell biology, fluid dynamics, mechanistic modeling for chromatography, protein chemistry, and knowledge in other functional areas (upstream and analytical sciences).
• Experience working in a cGMP or clean‑room setting (knowledge of GMP is helpful for process/tech transfer activities).

• Experience analyzing data in tools such as JMP, R, or Python.
• General understanding of cell biology, fluid dynamics, mechanistic modeling for chromatography, and protein chemistry.

• Base pay range at commencement of employment: $154,000 to $174,000. Base salary may vary based on skills, experience, and competitive market value.
• Additional total rewards include discretionary annual bonus, comprehensive benefits (Medical, Dental, Vision), short‑term and long‑term disability, company‑paid basic life insurance, 401(k) company match, flexible work, generous paid time off and holidays, wellness and transportation benefits.

Evotec (US) Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, gender, age, disability, genetic information, gender expression, gender identity, national origin, religion, sexual orientation, or veteran status.