Research Associate I​/II – Clinical Pathology​/IHC Biomarker Development

Syst Immune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi‑specific, multi‑specific antibodies, and antibody‑drug conjugates (ADCs). Syst Immune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications and a robust preclinical pipeline of potential cancer therapeutics in the discovery and IND‑enabling stages.

We are seeking a highly organized and detail‑oriented Research Associate I/II to support the development, optimization, and validation of immunohistochemistry (IHC) assays. This bench‑focused position requires close collaboration with scientists, pathologists, and cross‑functional project teams.

• Perform tissue sectioning of FFPE blocks
• Route and support H&E staining workflows

• Perform routine IHC staining on FFPE tissue specimens using automated platforms (e.g., Ventana, Leica)
• Conduct antibody titrations, protocol optimization, slide preparation, and quality control checks
• Assist in generating feasibility, optimization, and analytical validation data for emerging CDx assays
• Experience with Akoya Pheno Imager HT platforms is preferred

• Manage tissue samples and associated documentation
• Prepare tissue sections, including slide cutting, baking, antigen retrieval, and reagent preparation
• Maintain sample integrity, traceability, and documentation in compliance with quality system requirements
• Support tissue handling workflows (blocks, slides, labeling, storage) within GLP or CLIA/CAP environments

• Accurately record experimental data in ELN and/or LIMS systems
• Capture high‑quality slide images and perform basic image analysis
• Assist with slide scoring preparation and data summaries
• Summarize experimental findings for internal meetings and assay development reviews

• Operate, calibrate, and troubleshoot automated IHC staining platforms and related laboratory equipment
• Perform routine instrument maintenance and maintain equipment logs per laboratory quality systems
• Monitor and manage inventory of reagents, antibodies, controls, and consumables

• Collaborate with scientists, pathologists, QA, and clinical development teams on assay transfer, optimization, and validation activities
• Support preparation of study materials, controlled documents, and protocol execution for validation studies

• BS or MS in Biology, Molecular Biology, Pathology, Biomedical Sciences, or a related field
• 1–3 years of hands‑on experience in histology and/or IHC assay execution within a research or regulated diagnostic laboratory
• Experience handling FFPE tissues and operating automated IHC staining platforms
• Strong attention to detail with excellent documentation and record‑keeping practices
• Ability to follow SOPs and work effectively in CLIA, GxP, or ISO‑regulated environments

• Experience supporting IHC assay optimization and/or analytical validation studies
• Exposure to Akoya platforms and multiplex immunofluorescence projects
• Experience with digital pathology, slide scanning, or image analysis tools
• Knowledge of antibody characterization and tissue‑based biomarker assay development

The expected base salary range for this position is $60,000 – $80,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.

• 100% paid employee premiums for medical, dental, and vision
• Short‑term and long‑term disability coverage
• 401(k) plan with a 50% company match up to 3% and a 5‑year vesting schedule
• 15 paid time off days per year, sick leave, and 11 paid holidays
• Additional benefits as a leading biotech company

Syst Immune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.