Senior Scientist - Antibody Discovery at Systimmune Redmond, WA

Senior Scientist - Antibody Discovery (Syst Immune)

Location:

Redmond, WA.

Syst Immune is a leading clinical‑stage biopharmaceutical company focused on developing innovative cancer treatments, including bi‑specific antibodies, multi‑specific antibodies, and antibody‑drug conjugates (ADCs). The company has assets in various stages of clinical trials for solid tumors and hematologic indications, and a robust preclinical pipeline of potential therapeutics.

We are seeking a highly skilled Senior Scientist to join our Antibody Discovery Group. The role involves advancing antibody discovery efforts through target analysis, immunogen design, B‑cell sorting, flow cytometry, ELISA, and yeast library screening in a dynamic and innovative environment.

• Perform in-depth analysis of potential targets, including clinical landscape, biology, protein structure, and literature review.
• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high‑throughput sorting to isolate specific B‑cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze and compare BCR sequences and immune repertoires.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross‑functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

• Ph.D. in Immunology, Molecular Biology, Biochemistry, or related field.
• 3+ years of experience in B‑cell sorting and screening using flow cytometry, ELISA, and biolayer interferometry.
• 3+ years of experience in yeast library preparation, culture, and screening.
• Knowledge of antibody structure required; general knowledge of structural biology is a plus.
• Extensive knowledge of B‑cell immunology and antibody development.
• Extensive knowledge of cancer immunology.
• Proven contribution to therapeutic antibody development desirable.
• Experience in NGS library preparation and BCR repertoire analysis desirable.

• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong background in ELISA assay development and optimization.
• Expertise in molecular biology techniques related to yeast display libraries.
• Familiarity with data analysis software and statistical tools (Flow Jo, OCTET, Graph Pad Prism, Geneious Prime).

• Excellent problem‑solving and troubleshooting abilities.
• Strong organizational and time‑management skills.
• Ability to work independently and as part of a team.
• Effective communication skills, both written and verbal.

The role is performed in a molecular biology laboratory alongside other scientists and in a standard business office with desktop equipment and a moderate noise level.

Regular sitting for long periods. Ability to operate standard laboratory and business equipment.

The base salary range is $90,000 – $140,000 annually. Compensation depends on qualifications, experience, and skills.

The company offers a comprehensive benefits package, including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with 50% company match, 15 PTO days per year, sick leave, and 11 paid holidays.

Syst Immune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.