Research Associate I​/II I-O

Research Associate I/II

Syst Immune Inc. is seeking a motivated Research Associate I/II to join the Bioassay team within the Immuno-Oncology department. This role will support the engineering of complex cell lines and the execution of cell-based immunoassays to enable the discovery and development of novel cancer therapeutics. The ideal candidate will be a strong experimentalist with direct experience in genetic modification (such as lentiviral transduction and knock-in/out) and bioassay execution who thrives in a fast-paced, collaborative environment.

This is a hands-on laboratory role focused on critical materials generation, assay execution, and data analysis. The successful candidate will maintain high-quality experimental standards while developing deep technical expertise in immuno-oncology drug development.

This role is full-time onsite in Redmond, WA and will move to Bothell, WA fall 2026.

Key Responsibilities:

• Engineer stable cell lines using lentiviral transduction, CRISPR knock-ins, and knock-outs
• Analyze complex datasets, prepare technical reports, and present findings to internal teams.
• Perform rigorous batch qualification of critical reagents and cell lines to ensure assay consistency.
• Maintain and manipulate complex co-cultures of primary immune cells and engineered cancer cell lines.
• Conduct functional assays using Incucyte live-cell imaging, flow cytometry, and ELISA-based platforms.
• Develop, optimize, and validate cell-based and immunoassays to support drug development programs.

Qualifications:

Research Associate I:

• BS or MS in Biology, Immunology, Cell Biology, Bioengineering, Biochemistry, or related scientific field
• Minimum 1+ year of industry laboratory experience (internships may be considered if highly relevant)
• Hands-on experience with mammalian cell culture techniques and aseptic techniques
• Exposure to genetic modification workflows such as transient transfections or lentiviral transduction
• Basic familiarity executing immunoassays such as ELISA or flow cytometry
• Strong organizational skills and attention to detail
• Ability to work effectively in a team environment

Research Associate II:

• BS or MS in a relevant scientific discipline
• Typically, 2–4 years of relevant industry experience
• Direct experience engineering cell lines, including executing lentiviral transductions and knock-ins
• Proven track record executing and troubleshooting cell-based assays and flow cytometry workflows
• Demonstrated ability to work with moderate independence

Preferred Qualifications:

• Experience supporting oncology, immuno-oncology, immunology, or biologics drug discovery programs.
• Experience with single-cell cloning, CRISPR/Cas9 workflows, or stable cell line selection.
• Proficiency with Incucyte live-cell imaging, multi-color flow cytometry, or MSD multiplex platforms.
• Exposure to high-throughput research settings or regulated laboratory environments.
• Strong data analysis software skills (e.g., Graph Pad Prism, Flow Jo) and scientific communication skills

Compensation and Benefits:

The expected base salary range for this position is 60,000 - 80,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate's level qualifications, experience, and skills.

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

Syst Immune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. Syst Immune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

Syst Immune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.