Accounting Manager

Programmable Medicine is a pre-revenue, clinical-stage biotechnology company focused on discovering and developing innovative therapies for patients with serious diseases. The company operates across multiple legal entities and partners with external CROs, CMOs, and research institutions globally. Backed by leading venture capital investors, Programmable Medicine is building a scalable technical operations function to support rapid growth and pipeline advancement.

The Accounting Manager will be a hands-on, individual-contributor role supporting the accounting operations of a multi-entity biotech development organization. This role executes and owns key aspects of the close process, maintains accurate financial records, and applies strong technical accounting judgment to complex areas including clinical and nonclinical accruals, revenue recognition, and cost accounting. This is an experienced-level position: the ideal candidate operates independently, brings a strong technical accounting foundation, and can serve as a working-level resource to the Controller on technical matters.

This role partners closely with FP&A, providing significant support around clinical and non-clinical accrual estimates, actuals, and variance analysis.

Candidates must be able to work full days, on site, at our corporate headquarters in Redwood City, a minimum of 3 days per week and as required based on business needs.

• Execute assigned key components of the monthly, quarterly, and annual close process
• Prepare journal entries, account reconciliations, and supporting schedules across multiple legal entities
• Own the preparation and review of clinical and nonclinical accrual estimates in close partnership with FP&A and clinical/program stakeholders, ensuring accuracy and timely reporting of actuals and variances
• Process and record intercompany transactions across the multi-entity structure, including recording pass-through costs, reclass entries between entities, and intercompany billings with cost-plus markups; reconcile intercompany balances
• Apply technical accounting judgment to support revenue recognition under ASC 606, including contract- and milestone-based arrangements common in CRO/CDMO environments
• Support cost accounting activities, including inventory, standard costing, and manufacturing variance analysis
• Research and document technical accounting positions and memos, escalating and partnering with the Controller on judgmental or complex matters
• Ensure adherence to U.S. GAAP and company accounting policies
• Maintain and strengthen internal controls, including documentation and audit support
• Prepare schedules and documentation for external audits and tax compliance
• Provide accurate, well-supported financial data and accounting analysis to FP&A, including actuals and variance support
• Identify and help drive process improvements and automation within accounting
• Support ERP system integrity and reporting enhancements

• Bachelor's degree in accounting or finance; CPA or CPA-track preferred
• 5+ years of progressive accounting experience, preferably including CRO, CDMO, or biotech/pharma
• Demonstrated technical accounting expertise, with the judgment to research and document positions independently
• Experience with clinical trial or R&D-related accrual accounting strongly preferred
• Experience with intercompany transaction accounting in a multi-entity environment, consolidation experience a plus but not required
• Strong working knowledge of revenue recognition (ASC 606), including contract- and milestone-based arrangements
• Exposure to cost or inventory accounting preferred
• Experience with ERP systems (e.g., Sage Intacct, Net Suite, SAP, Oracle)
• Advanced Excel skills
• High degree of ownership, attention to detail, and accuracy in a hands-on capacity
• Comfortable operating independently in a lean, fast-paced environment with no direct reports
• Clear and effective communication with cross-functional stakeholders, including FP&A, clinical operations, and executive leadership

We have a comprehensive total compensation package including fully paid medical, dental, and vision benefits for you and your family. The Company also offers participation in the annual bonus program along with a new hire equity program. The salary range for candidates located in the Bay Area is $135,000 - $158,000annually. We consider various factors when determining the base compensation, including market survey data, experience, and directly…