Manager, GMP Supply Planning & Procurement

Who We Are

Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.

Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.

Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.

Arcellx Core Values

• Start with authenticity:
  We foster an inclusive environment where each person can bring their authentic self to work.
• Think ‘we’ before ‘me’:
  We prioritize collective success, collaborating and supporting one another to achieve our shared goals.
• Embrace the challenge:
  We deliver exceptional results by working with shared determination and a commitment to doing what’s right.

In this role, you’ll ensure uninterrupted, compliant, and efficient supply of GMP raw materials, consumables, and services to support Arcellx’s manufacturing operations. This role combines strategic planning, supplier risk management, and tactical execution, with ownership for Arcellx manufacturing supply operations and broader supply chain activities.

• GMP Material Planning & Availability Management
• Execute material requirements planning (MRP) for GMP manufacturing, gowning, and operational needs.
• Establish and maintain safety stock levels, reorder points, and reorder quantities.
• Translate forecast changes and production schedules into actionable material plans.
• Develop scenario-based planning to address variability in production schedules, patient demand and supplier lead times.
• Procurement Operations & Process Ownership
• Develop, maintain, and continuously improve compliant SOPs, work instructions, and process controls for P2P and S2D.
• Ensure workflows, master data, integrations, and reporting are audit-ready and aligned with regulatory expectations.
• Purchase Order Execution & System Management
• Execute the end-to-end purchase order lifecycle in the ERP and Clear Spider systems.
• Manage PO creation, review, issuance, tracking, changes, transfers, returns, and replacements.
• Ensure accuracy, timeliness, and compliance with GMP and operational requirements.
• Supplier Management & Performance Oversight
• Support the maintenance of strong, compliant supplier relationships.
• Support and where applicable, drive supplier issue resolution, complaint management, and follow-up activities.
• Track, trend, and report supplier performance metrics, including OTIF, lead-time adherence, and service reliability.
• Supplier Change, Alternate & Substitute Strategy Execution
• Monitor and support supplier-driven material changes, including notifications, impact assessments, qualification support, and discontinuations.
• Define and execute alternate and substitute material strategies to mitigate supply risk.
• Coordinate implementation and lifecycle management of alternate/substitute materials with Quality, Manufacturing, and Technical Operations.
• Strategic Sourcing, Contracts & Supply Continuity
• Manage GMP raw material supplier contracts, including pricing, lead times, service levels, and commercial terms.
• Support sourcing, negotiation, and contract execution across the organization.
• Lead second-sourcing and supply continuity initiatives to reduce single-source dependency and improve resilience.
• Risk Management, Escalation & Audit Readiness
• Identify critical material risks, including long-lead, single-source, and capacity-constrained items.
• Develop mitigation plans and elevate risks to supply chain leadership.
• Ensure procurement, supplier, and material planning records are…