Scientist II, Cancer Pharmacology, Translational Research

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a Scientist II in the Translational Research team, within the Biology Department, you will:

* As a member of a cross-functional quantitative modeling group, collaborate with team members to develop, validate and refine physiologically-based PK (PBPK), quantitative systems pharmacology (QSP), and semi-mechanistic PK/PD models to support discovery and development-phase projects.

* Seek and apply innovative modeling approaches to understand tumor resistance to RAS(ON) inhibitors and build in silico models, propose mechanistic in vitro and in vivo experiments to test model assumptions and structure.

* Design and oversee in vivo and ex vivo studies (internally and via CROs), develop and maintain high-quality protocols and documentation, and present results at internal forums and scientific conferences.

Required Skills, Experience and

Education:

* Ph.D. in pharmacology or cancer biology, or a quantitative discipline (pharmaceutical sciences, mathematics, systems pharmacology, computational biology, etc.) with direct relevance to drug development.

* 2+ years of relevant postdoc or industry experience in cancer drug discovery and development.

* Demonstrated experience in in vivo experiments with oncology disease models.

* Solid PK/PD knowledge and prior experience with PK/PD data collection and analysis.

* A strong theoretical understanding of the core concepts, assumptions, and limitations associated with PK/PD mathematical modeling

* Rigorous, quantitative and detail-oriented with proven excellence in experimental design, data analysis, data management, and presentation.

* Excellent written and verbal communication skills. Able to effectively communicate modeling assumptions, limitations, and simulation results to non-specialist and specialist audiences.

* Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.

* Thrives in a collaborative team setting and is driven by a desire to be innovative in a dynamic and fast-paced environment.

Preferred

Skills:

* An understanding of preclinical to clinical translational concepts desired.

* Strong track record of research productivity as evidenced by high-quality, impactful publications.

* Experience with development, calibration, and validation of ordinary differential equation (ODE) and non-linear mixed effect (NLME) models.

* Hands on experience with modeling software (Simbiology, Phoenix Win Nonlin, NONMEM, etc.) and PBPK model development.

#LI-Hybrid #LI-NE1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location.

Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at Rev Med, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range

$128,000-$160,000 USD