Scientist III​/IV, Immunology

We are seeking a driven, energetic, results‑oriented Scientist III / Scientist IV to join the Biomarker Discovery group within the Immunology and Respiratory Research Therapeutic Area in Ridgefield, CT. This individual will develop in vitro target engagement (TE), pharmacodynamic (PD), and disease biomarker assays to support Immunology and Respiratory portfolio projects and will use innovative technologies to discover biomarkers that advance novel research programs.

• Act as a technology expert to develop and implement experimental approaches that contribute to Biomarker Discovery group goals independently and efficiently.
• Design, execute, and troubleshoot routine and innovative TE/PD and disease biomarker assays using animal and human matrices; analyze data, interpret outcomes, and propose follow‑up plans.
• Collaborate with colleagues within the Biomarker Discovery group and across functions to move new therapeutic concepts through their lifecycle.
• Keep abreast of relevant scientific literature and extract applicable information from published methods, protocols, and emerging technologies.
• Present scientific work at internal and external meetings.
• Propose and contribute to the incorporation of new technologies and assume departmental responsibility for technical aspects of portfolio projects.
• Train junior scientists in laboratory operations and share technical expertise across the department.
• Co‑author peer‑reviewed manuscripts, technical reports, and internal scientific documents.
• Adopt best practices, comply with regulations, perform all work safely, and maintain records in accordance with SOPs and company policies.

• Independently execute defined biomarker assays and technical work streams.
• Serve as a technical owner for specific assays, platforms, or studies.
• Contribute to data interpretation and scientific input to project teams.
• Support multiple programs with increasing scientific autonomy.

• Act as a biomarker lead or co‑lead for portfolio projects.
• Drive biomarker strategy, assay selection, and translational framing for programs.
• Integrate biomarker data across platforms to inform project‑level decisions.
• Provide scientific mentorship and technical leadership within the group.
• Represent Biomarker Discovery in cross‑functional project discussions.

• Strong hands‑on experience with immunoassay development, including cell‑based and ligand‑binding assays.
• Experience with standard laboratory techniques such as mammalian cell culture, human, cynomolgus, and murine blood handling, blood product preparation, peripheral blood cell isolation and culture, DNA/RNA extraction, RT‑qPCR, and western blotting.
• Ability to learn and apply new technologies and scientific concepts.
• Proficiency in Microsoft Office; experience with flow cytometry data analysis tools (e.g., Flow Jo) and Graph Pad Prism.
• Strong verbal and written communication skills.
• Independent thinker with the ability to plan, execute, and adapt technical activities.
• Strong analytical skills to interpret, summarize, and present experimental data and related findings.
• Master’s Degree with 3+ years experience in a related scientific discipline or Bachelor’s Degree with 7+ years experience in a related field (Scientist III). For Scientist IV:
  Master’s Degree with 6+ years or Bachelor’s with 10+ years experience.

• Experience with direct and indirect target engagement (TE) assays and receptor/target occupancy assays.
• Hands‑on experience with flow cytometry, including assay development and data interpretation.
• Experience with patient sample handling, processing, and documentation.
• Hands‑on experience with primary human fibroblasts, including culture and experimental manipulation.

The base salary range for the Scientist III position is $90,000.00 to $. The position may be eligible for role‑specific discretionary bonus, relocation, and/or other compensation elements. Salary adjustments may occur based on market data and job‑related factors.

For more information on benefits, visit