Scientist II

Scientist II – In Vivo Pharmacology / Cardio-Renal Research
Ridgefield, CT (Onsite)
24-Month Contract
Sigma Inc

Sigma Inc. is seeking a motivated Scientist II to join our research team in Ridgefield, CT. This onsite role is ideal for a hands-on scientist with strong in vivo experience and a background in cardiometabolic or cardio-renal biology who can work both independently and collaboratively in a fast-paced environment.

• Independently initiate and execute routine in vivo studies with minimal supervision
• Interpret experimental results and recommend next steps or follow-up studies
• Support the development and validation of rodent models for cardiometabolic diseases
• Design and conduct studies involving cardio-renal disease models (e.g., kidney injury, cardiovascular dysfunction, metabolic disorders)
• Perform dosing procedures including oral gavage, IP/IV/SC injections
• Conduct physiological and functional assessments such as blood pressure monitoring, telemetry, metabolic cage studies, and renal assays
• Collect and process biological samples (blood, urine, tissues) for downstream analysis
• Perform assays including histology, qPCR, ELISA, and biomarker analysis
• Analyze data and maintain high-quality documentation in compliance with SOPs and regulatory standards
• Collaborate cross-functionally with pharmacology, pathology, and bioanalytical teams
• Contribute to scientific discussions, presentations, and technical reports
• Propose and implement improvements based on scientific knowledge and literature insights
• Operate, maintain, and troubleshoot laboratory equipment
• Ensure compliance with IACUC protocols, safety standards, and ethical animal care guidelines

• Bachelor’s degree in a scientific discipline with 3+ years of relevant experience, OR
• Master’s degree with 2–3 years of relevant experience
• Experience in pharmaceutical, biotechnology, or CRO environments preferred
• No PhD candidates, please
• Strong understanding of physiology, pharmacology, and cardio-renal disease mechanisms
• Hands-on experience with:
  • In vivo rodent models (rats and mice)
  • Dosing techniques (oral gavage, injections)
  • Physiological monitoring and functional assays
  • Sample collection and processing
  • Molecular/biochemical assays (qPCR, ELISA, histology)
• Ability to independently design, execute, and troubleshoot experiments
• Strong data analysis, interpretation, and documentation skills
• Excellent written and verbal communication skills
• Proficiency with scientific software and data tools

• Ability to work in a vivarium and laboratory setting, including:
  • Standing for extended periods (>2 hours)
  • Working under biosafety cabinets
  • Lifting up to 20 lbs, bending, and reaching
• Daily handling and restraint of small laboratory animals (rats, mice; >50 at a time)
• Use of appropriate personal protective equipment (PPE)
• Willingness to support weekend work as needed
• Ability to thrive in a collaborative, fast-paced research environment

• Prior experience in cardio-renal or metabolic disease research
• Familiarity with drug discovery and development processes
• Experience contributing to scientific reports, presentations, or publications