Scientist II

Job Title:
Scientist II
Duration: 12 months

Location:

Ridgefield, CT 06877

Job Description:
" Independently initiates and completes routine in vivo studies efficiently, with minimal supervision. Interprets experimental outcomes and recommends appropriate follow-up.
" Demonstrates technical proficiency supporting the development and validation of rodent models for cardiometabolic diseases.
" Applies basic scientific principles with minimal guidance; performs literature searches and extracts relevant information from published protocols.
" Proposes new ideas and technologies, builds support, and implements improvements based on scientific and technical expertise. and an understanding of the drug discovery and development process.
" Independently operates and maintains laboratory equipment and troubleshoots issues effectively.
" Communicates work effectively, both orally and in writing; contributes to protocols, procedures, and technical reports; and provides input for scientific reports.
" Records, analyzes, and reports data with a high level of integrity and ethical conduct.
" Complies with applicable regulations and performs all work safely; maintains accurate records in accordance with Standard Operating Procedures and policies.

Skills:
" Contributes to design and execution of in vivo studies relevant to cardio-renal metabolic diseases (kidney injury, cardiovascular and metabolic driven cardio-renal dysfunction.)
" Perform dosing procedures (oral gavage, IP/IV/SC injections), physiological monitoring, and sample collection (blood, urine, tissues).
" Conduct functional assessments, such as blood pressure measurements, echocardiography support, telemetry, metabolic cage studies, and renal function assays.
" Process and analyze biological samples, including histology, biomarker assays, qPCR, ELISA, and other molecular or biochemical readouts.
" Maintain high-quality documentation, including study protocols, animal records, raw data, and reports compliant with internal and regulatory standards.
" Collaborate cross functionally with pharmacology, pathology, bioanalytics, and therapeutic area biology teams to interpret data and refine study designs.
" Ensure compliance with IACUC protocols, ethical animal care standards, and institutional guidelines.
" Contribute to scientific discussions, present data at team meetings, and support preparation of internal reports and external publications.
" Requires moderate physical activity to perform work in the vivarium and laboratory, including (but not limited to) standing for extended durations (> 2 hours), working under a biosafety hood/cabinet for extended durations (> 2 hours), bending, lifting (up to 20 lbs), squatting, pushing/pulling, and reaching. Also requires daily handling and restraint of small laboratory animals (rats, mice; > 50 at a time), often within a specified timeframe.

" Requires use of personal protective equipment (PPE), including respiratory, eye, hand, and foot protection.
" Ability and willingness to work effectively in a highly collaborative environment and support weekend work as needed.
" Strong communication skills and ability to work collaboratively in a fast paced research environment.

Education:
" Master's Degree with 2-3 years experience or Bachelor's Degree with 3 years experience in related scientific discipline; pharmaceutical, biotechnology or CRO experience is highly desirable; non-PhD applicant required.
" Understanding of physiology, pharmacology, and disease mechanisms relevant to cardio renal biology.