Scientist II

Scientist II - 12-Month Contract - Ridgefield, CT (Onsite)

Sigma Inc. is seeking an experienced Scientist II to join a leading pharmaceutical research team in Ridgefield, CT. This is an excellent opportunity for scientists with hands-on laboratory experience in analytical chemistry, biopharmaceutical development, therapeutic modalities, chromatography, and formulation development. The ideal candidate will thrive in a fast-paced R&D environment supporting innovative drug development programs.

If you have expertise in HPLC, SEC, Field Flow Fractionation (FFF/AF4), wet chemistry, formulation preparation, and analytical characterization, we encourage you to apply.

• Perform laboratory experiments supporting development of new therapeutic modalities including peptides, oligonucleotides, antibodies, viral and non-viral delivery systems.
• Design, execute, analyze, and document scientific experiments with minimal supervision.
• Independently perform routine and non-routine laboratory procedures.
• Prepare buffers, mobile phases, formulations, and other laboratory reagents.
• Utilize analytical techniques including HPLC, SEC, Field Flow Fractionation (FFF/AF4), and related chromatography methods.
• Operate, troubleshoot, calibrate, and maintain laboratory equipment.
• Analyze experimental data and prepare technical reports, protocols, SOPs, and scientific documentation.
• Present scientific findings during project meetings and cross-functional team discussions.
• Conduct literature reviews and apply scientific findings to ongoing research projects.
• Maintain laboratory organization, reagent inventory, and documentation.
• Ensure compliance with laboratory safety standards, GMP practices, company policies, and regulatory requirements.
• Collaborate with multidisciplinary research teams to support product and process development.

• Bachelor's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, Biology, Chemical Engineering, or related scientific discipline with 5+ years of laboratory experience

OR

• Master's degree with 4+ years of relevant laboratory experience
• Strong experience with wet chemistry preparation methods including buffers, mobile phases, and multi-component formulations.
• Hands-on experience with analytical chromatography techniques including:
• HPLC
• SEC (Size Exclusion Chromatography)
• Field Flow Fractionation (FFF/AF4)
• Experience planning, executing, interpreting, and documenting laboratory experiments.
• Strong scientific writing and technical documentation skills.
• Excellent verbal and written communication skills.
• Ability to work independently while collaborating within cross-functional teams.
Preferred Qualifications

Experience with one or more of the following is highly desirable:

• NMR Spectroscopy
• Dynamic Light Scattering (DLS)
• Flow Cam Particle Analysis
• Fluorescent Labeling
• Microscopy
• Image Analysis
• DNA/RNA Isolation
• PCR
• Electrophoresis
• Biophysical Characterization
• Drug Delivery Systems
• Biotherapeutics Development
Technical Skills
• HPLC
• SEC
• FFF / AF4
• Wet Chemistry
• Analytical Chemistry
• Pharmaceutical Research
• Laboratory Instrumentation
• Method Development
• Scientific Documentation
• SOP Writing
• Technical Reports
• Experimental Design
• Data Analysis
• Formulation Development
• Biopharmaceutical Research