Postdoctoral Fellow – Lipotoxicity and Liver Inflammation Laboratory

Postdoctoral Fellow Opportunity

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. We are dedicated to our employees, investing in competitive compensation and comprehensive benefit plans to take care of you and your family, now and in the future. With continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

• Medical:
  Multiple plan options.
• Dental:
  Delta Dental or reimbursement account for flexible coverage.
• Vision:
  Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement:
  Competitive retirement package to secure your future.

Responsibilities

We seek a highly motivated postdoctoral fellow with a strong background in liver pathobiology or vascular biology and immunology to join the Lipotoxicity and Liver Inflammation Laboratory. This role will support research focused on dissecting cellular and molecular mechanisms driving metabolic dysfunction-associated steatohepatitis (MASH), lipotoxic endotheliopathy, mitochondrial dysfunction, immune interactions, and identification of mechanism-based therapeutic targets.

Key Responsibilities

• Conduct independent and collaborative research to investigate mechanisms of liver injury, inflammation, and vascular dysfunction in MASH.
• Design and execute experiments using in vitro and in vivo models of lipotoxic liver disease.
• Perform advanced molecular and cellular biology techniques, including but not limited to plasmid cloning, gene expression analysis, protein assays, and cell signaling studies.
• Isolate and characterize primary liver cells, including intrahepatic leukocytes, hepatocytes and liver sinusoidal endothelial cells.
• Manage and perform rodent handling and interventions, including diet-induced MASH models and genetic or pharmacologic manipulations.
• Apply flow cytometry, immunohistochemistry, and immunofluorescence techniques to assess cell populations and pathological changes.
• Perform basic bioinformatic analysis (e.g., RNA-seq) and interpret complex datasets.
• Participate in manuscript preparation, presentations, and grant writing.

What You Will Gain

• Training in cutting-edge methodologies relevant to liver disease and immunometabolism.
• Collaborative environment at a leading academic medical research center.
• Opportunity to contribute to high-impact publications and translational research advancing therapeutic strategies for MASH.

Qualifications

Required Qualifications

• Ph.D. in Physiology and biomedical engineering, biochemistry and molecular biology, immunology, vascular biology, or related biomedical discipline.
• Demonstrated expertise in liver pathobiology and basic molecular and mechanistic techniques.
• Hands-on experience with animal handling, including approval and conduct of rodent studies.
• Proven ability with plasmid cloning, gene manipulation, and cell isolation procedures.
• Competence in basic bioinformatic data analysis (e.g., differential gene expression, pathway analysis).
• Solid background in immunology, particularly as related to inflammation and cellular crosstalk.
• Familiarity with vascular biology or endothelial cell function in organ pathology is highly desirable.

Preferred Skills

• Use of omics approaches to understand tissue zonation and cell interactions.
• Experience in studying intercellular signaling.
• Strong written and oral communication skills suitable for presentations and publications.