Postdoctoral Fellow - Lipotoxicity and Liver Inflammation Laboratory

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

* Medical:
Multiple plan options.

* Dental:
Delta Dental or reimbursement account for flexible coverage.

* Vision:
Affordable plan with national network.

* Pre-Tax Savings: HSA and FSAs for eligible expenses.

* Retirement:
Competitive retirement package to secure your future.

Responsibilities

We seek a highly motivated postdoctoral fellow with a strong background in liver pathobiology or vascular biology and immunology to join the Lipotoxicity and Liver Inflammation Laboratory. This role will support research focused on dissecting cellular and molecular mechanisms driving metabolic dysfunction-associated steatohepatitis (MASH), lipotoxic endotheliopathy, mitochondrial dysfunction, immune interactions, and identification of mechanism-based therapeutic targets.

Key Responsibilities

* Conduct independent and collaborative research to investigate mechanisms of liver injury, inflammation, and vascular dysfunction in MASH.

* Design and execute experiments using in vitro and in vivo models of lipotoxic liver disease.

* Perform advanced molecular and cellular biology techniques, including but not limited to plasmid cloning, gene expression analysis, protein assays, and cell signaling studies.

* Isolate and characterize primary liver cells, including intrahepatic leukocytes, hepatocytes and liver sinusoidal endothelial cells.

* Manage and perform rodent handling and interventions, including diet-induced MASH models and genetic or pharmacologic manipulations.

* Apply flow cytometry, immunohistochemistry, and immunofluorescence techniques to assess cell populations and pathological changes.

* Perform basic bioinformatic analysis (e.g., RNA-seq) and interpret complex datasets.

* Participate in manuscript preparation, presentations, and grant writing.

What You Will Gain

* Training in cutting-edge methodologies relevant to liver disease and immunometabolism.

* Collaborative environment at a leading academic medical research center.

* Opportunity to contribute to high-impact publications and translational research advancing therapeutic strategies for MASH.

Qualifications

Required Qualifications

* Ph.D. in Physiology and biomedical engineering, biochemistry and Molecular Biology, Immunology, Vascular Biology, or related biomedical discipline.

* Demonstrated expertise in liver pathobiology and basic molecular and mechanistic techniques.

* Hands-on experience with animal handling, including approval and conduct of rodent studies.

* Proven ability with plasmid cloning, gene manipulation, and cell isolation procedures.

* Competence in basic bioinformatic data analysis (e.g., differential gene expression, pathway analysis).

* Solid background in immunology, particularly as related to inflammation and cellular crosstalk.

* Familiarity with vascular biology or endothelial cell function in organ pathology is highly desirable.

Preferred Skills

* Use of omics approaches to understand tissue zonation and cell interactions.

* Experience in studying intercellular signaling.

* Strong written and oral communication skills suitable for presentations and publications.

Exemption Status

Exempt

Compensation Detail

$67,282.95 - $78,711.15 / year;
Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Monday - Friday

Weekend Schedule

as needed

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives.

Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'. Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter

Kara Schott