Postdoctoral Research Fellow - T Cell Engineering Lab

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

• Medical:
  Multiple plan options.
• Dental:
  Delta Dental or reimbursement account for flexible coverage.
• Vision:
  Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement:
  Competitive retirement package to secure your future.

The T Cell Engineering Laboratory (Kenderian Laboratory) at Mayo Clinic is seeking a highly motivated and talented Postdoctoral Research Fellow to lead and contribute to the development of next-generation engineered cell therapies for cancer and immune-mediated diseases. Our laboratory is recognized for its work in CAR T cell biology, synthetic and logic-gated cell therapies, mechanisms of resistance and toxicity, and translational immunotherapy, with a strong emphasis on moving discoveries from bench to clinic.

The successful candidate will work in a highly collaborative, well-resourced environment with direct access to GMP manufacturing, clinical trials, and multidisciplinary translational teams.

This Position Is Ideal For Individuals Aspiring To Careers In Academic Medicine, Biotechnology, Or Translational Research Leadership. The Postdoctoral Fellow Will Have The Opportunity To Lead Independent And Collaborative Projects In Areas Including (but Not Limited To):

• Design and engineering of next-generation CAR T and other engineered immune cell therapies
• Synthetic biology approaches (e.g., logic-gated receptors, syn Notch, armored CARs)
• Overcoming tumor immune evasion, antigen loss, exhaustion, and senescence
• Mechanisms of on-target/off-tumor toxicity and immune-related adverse events
• Translational studies bridging preclinical models, GMP manufacturing, and early-phase clinical trials
• Solid and hematologic malignancies, with opportunities for cross-platform innovation

Projects will be tailored to the Fellow’s expertise and career goals, with strong encouragement and support for first-author high-impact publications and independent funding applications. The Laboratory offers a unique translational ecosystem, including:

• State-of-the-art BSL-2+/cell engineering laboratories
• Access to GMP cell manufacturing through the Center for Regenerative Biotherapeutics
• Close interaction with clinician-scientists, immunologists, bioengineers, and industry collaborators

• Grant writing (NIH K99/R00, foundation awards)
• Manuscript preparation for top-tier journals
• Scientific presentation and leadership development
• Career advancement in academia or industry

Required qualifications:

• Ph.D., M.D., or M.D./Ph.D. in Immunology, Cancer Biology, Bioengineering, Molecular Biology, or a related field.
• Strong background in cellular or molecular immunology or cancer biology.
• Demonstrated productivity with peer-reviewed publications.
• Excellent written and verbal communication skills.
• High level of independence, creativity, and scientific rigor.

Preferred qualifications (not required):

• Experience with T Cell Biology, CAR T Cell Engineering, or Adoptive Cell Therapy.
• Expertise in one or more of the following: viral or non-viral gene delivery, flow cytometry and immune phenotyping, CRISPR/Cas9 or genetic engineering, in vivo mouse models, synthetic biology platforms, interest in translational or clinically oriented research.

Exemption Status:
Exempt

Compensation Detail: $67,282.95 - $78,711.15 per year;
Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible:
Yes

Schedule:

Full Time

Hours/Pay Period: 80

Schedule Details: M-F 8am-5pm; hours may vary depending on lab needs.

Weekend

Schedule:

Occasionally depending on the lab needs.

International Assignment:
No

Site

Description:

Employees located at Phoenix/Scottsdale, Arizona;
Jacksonville, Florida;
Rochester, Minnesota;
Mayo Clinic Health System campuses; and international locations.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Kara Schott