Program in Precision Genomics: Interventional Therapeutics

Recruitment of Basic and Translational Discovery Scientists in Gene Editing

Mayo Clinic's Department of Clinical Genomics, in collaboration with aligned departments and programs, seeks exceptional physicians and scientists, experts in the rapidly evolving field of genome editing and therapeutic delivery, to drive innovation at the intersection of discovery, translational, clinical research, and clinical practice. The Program in Precision Genomics:
Interventional Therapeutics (PG-IT) program at Mayo Clinic is a groundbreaking new initiative of highly innovative and creative scientists and physicians working collaboratively to advance next-generation molecular therapies by delivering genetically targeted treatments in vivo.

The PG-IT program will build on tremendous strengths at Mayo Clinic including:

• The Mayo Clinic Artificial Intelligence (AI) Program, driving the development of AI-based drug discovery, predictive models, large language models (LLMs), and AI agents within research and implemented into the Mayo Clinic clinical practice, powered by unparalleled partnerships and compute capabilities (NVIDIA SuperPOD DGX B200).
• Mayo Clinic Platform (MCP;(Use the "Apply for this Job" box below). ), the world's largest distributed federated healthcare data network with cloud-based storage of the fully digitized longitudinal patient records (including fully digitized radiographic images and pathology slide images, and sophisticated laboratory diagnostics) and associated research data and biospecimens from >50M patients at Mayo Clinic and MCP partners worldwide.
• Exceptional research and clinical programs, research infrastructure, shared research resources, and education and training programs to facilitate research in basic and clinical genomics and molecular engineering to precisely target genetic drivers of rare and complex conditions.
• A robust clinical research and clinical trials infrastructure that currently supports the delivery of the nation's largest number of clinical trials to the patients we serve, including new and novel and "first in human" therapies, including cellular, biologic, and genetic therapies.
• Mayo Clinic's unique collaborative ecosystem, which includes an integrated clinical practice, world-class research platforms, and advanced infrastructure for gene and cell-based therapeutic development.

Our goals for the Mayo Clinic PG-IT program include in vivo human gene editing for rare and inherited genetic disorders and complex human diseases, the acceleration of drug repurposing for genetically targeted indications, and identifying the most promising novel gene-editing interventions to benefit patients. This will help accelerate discovery and apply cutting-edge innovations in real-world settings. Areas of opportunity span therapeutic development, CRISPR- and RNA-based interventions, genome engineering, molecular diagnostics, novel mechanisms and modes of delivery of genetic therapies in vivo, and the deployment of genomics-enabled clinical care pathways for rare, inherited, and complex conditions.

Successful candidates will lead, design, and implement innovative genomic and translational approaches that improve patient outcomes while driving forward to the next generation of therapeutic and diagnostic discovery. These roles offer the opportunity to collaborate across Mayo Clinic's extensive research and clinical networks, including partnerships with the Mayo Clinic Laboratories, the Advanced Diagnostics Laboratory, extensive biopharma partnerships and collaborations, and enterprise-wide precision medicine initiatives.

Faculty will contribute to the development and integration of emerging genomic technologies into clinical and therapeutic pipelines, helping to shape programs that influence local, national, and global practice in genomic medicine. As the PG-IT Program builds it will gain SAGE (Standards for Advanced Gene Editing) certification for the customized delivery of human genetic interventions.

Mayo Clinic's values of teamwork, collaboration, and patient-centered care are foundational to deliver integrated research, medical, and surgical care for individuals with complex genetic and genomic conditions. Faculty members will receive academic appointments (Assistant, Associate, Full Professor and Consultant) within the Mayo Clinic College of Medicine and Science commensurate with experience, scholarly contributions, and leadership in clinical, research, or translational domains.

Mayo Clinic is committed to supporting the long-term success of faculty through robust research infrastructure, interdisciplinary mentorship, and a culture that values innovation, scientific excellence, and transformative patient impact. We are enthusiastic about the potential to work with visionary leaders in the field and look forward to the opportunity to make significant strides in genomic medicine together.