Scientist, Antibody Engineering

Job Title: Scientist Antibody Engineering
Location: Rockville, MD (Onsite)
Hours/

Schedule:

Monday–Friday, 9:00 AM – 5:00 PM
Compensation: $30–$40/hour
Type: Contract (6 months, potential for extension)

A leading biotechnology company advancing next-generation antibody-based therapeutics is seeking a Scientist / Associate Scientist to join their antibody engineering team. This role focuses on phage display, nanobody/antibody discovery, and bispecific engineering, supporting early-stage oncology programs. This is a highly hands-on opportunity to work on cutting-edge therapeutic platforms in a collaborative research environment.

• Contribute to the discovery and engineering of nanobodies and antibodies, including bispecific formats
• Perform bio-panning of phage libraries against selected targets to identify lead candidates
• Design, construct, and engineer antibody and nanobody constructs using molecular biology techniques
• Execute PCR, cloning, mutagenesis, RNA isolation, and sequence analysis
• Evaluate antibody/nanobody performance using ELISA, flow cytometry, and Octet
• Analyze binding, function, stability, and develop ability of candidates
• Support antibody library generation and screening workflows
• Utilize molecular and some computational tools to optimize affinity and stability
• Perform basic data analysis and interpretation of experimental results
• Document experimental procedures and findings in lab notebooks and internal systems
• Collaborate with cross-functional teams to advance discovery programs

• Bachelor’s degree with 3–5+ years of experience, OR Master’s with 1–2+ years, OR recent PhD in a relevant scientific discipline
• Direct experience with phage display / bio-panning - required
• Strong hands‑on experience in molecular biology techniques (cloning, mutagenesis, sequencing, plasmid work)
• Experience working with antibody or nanobody libraries is highly desirable
• Hands‑on experience with ELISA and/or flow cytometry for protein/antibody evaluation
• Familiarity with plasmid mapping and sequence analysis tools (e.g., Snap Gene)
• Exposure to NGS is a big plus
• Strong attention to detail, documentation skills, and ability to work in a fast‑paced lab environment

System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.