Computational Protein Engineer

We are recruiting for a research-driven biotechnology organization seeking a Computational Protein Engineer to lead hands‑on antibody and protein engineering programs in Rockville, Maryland. This position combines wet‑lab experimentation with computational design tools to accelerate discovery, guide design decisions, and improve experimental outcomes. The organization offers scientists meaningful independence, access to accomplished colleagues, and the opportunity to pursue creative research with long‑term impact.

• Lead antibody and protein engineering programs, including affinity maturation, multispecific antibodies, and novel binder development
• Develop protein expression, purification, and analytical characterization workflows across multiple formats
• Design binding, biochemical, and functional assays to evaluate engineered candidates
• Apply tools such as Alpha Fold, Rosetta, and ProteinMPNN to prioritize designs and guide laboratory strategies
• Partner with structural biologists and computational scientists to translate modeling insights into experimental programs
• Provide technical leadership across complex, multidisciplinary research initiatives
• Communicate findings, recommendations, and project progress to scientific stakeholders

• PhD in biochemistry, molecular biology, protein science, or a related discipline
• Industry experience conducting hands‑on antibody or protein engineering research
• Strong expertise in protein expression, purification, characterization, and assay development
• Experience with bispecific antibodies, nanobodies, multispecific proteins, or similar modalities
• Familiarity with computational protein design and structure‑prediction platforms
• Scientific contributions demonstrated through publications, patents, or successful development programs
• Ability to lead technical projects and collaborate across scientific disciplines