Scientist I​/II - Bioconjugation

Job Title

Scientist I/II

Macro Genics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 150+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. Macro Genics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

The Scientist I/II will be an integral member of the Targeted Therapeutics Group focused on generating novel antibody-based therapies for the treatment of cancers. The successful candidate will contribute to the design, synthesis, characterization, and optimization of antibody-drug conjugates (ADCs), degrader-antibody conjugates (DACs), and other targeted therapeutic modalities. This position offers an exciting opportunity to work in a fast-paced multidisciplinary environment advancing innovative cancer therapeutics from discovery through preclinical development, and into clinical development.

Design and execute antibody conjugation experiments using a variety of linker-payload technologies.

Develop and optimize bioconjugation processes for ADCs, DACs, and related targeted therapeutics.

Synthesize, and optimize novel linker-payload molecules, directly contributing to next-generation ADC therapies.

Purify, characterize, and analyze synthesized molecules using analytical techniques such as HPLC, FPLC, LC-MS, and NMR.

Evaluate conjugation efficiency, drug-to-antibody ratio (DAR), aggregation, stability, and product quality attributes.

Contribute to troubleshooting, process optimization, and scale-up activities.

Collaborate closely with cross-functional teams to advance ADC programs from early discovery through preclinical and clinical development stages.

Author protocols, research reports, and intellectual property documents, while maintaining high-quality electronic laboratory records

Education & Experience

Scientist I

• M.S. degree in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related field with 0-2 years of direct relevant experience.
• B.S. degree in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related field with 3-5 years of direct relevant experience.

Scientist II

• M.S. degree in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related field with 2-5 years of direct relevant experience.
• B.S. degree in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related field with 5-8 years of direct relevant experience.

Knowledge,

Skills and Abilities

• Hands-on experience in bioconjugation, protein conjugation, or antibody-drug conjugate development.
• Experience with purification and characterization techniques for both small molecules and bioconjugates.
• Strong understanding of protein chemistry, antibody structure, and conjugation methodologies.
• Experience operating analytical instruments such as HPLC, UPLC, LC-MS, SEC, and HIC.
• Excellent organizational, documentation, and communication skills.
• Ability to work independently while contributing effectively within cross-functional teams.
• Detail-oriented and well organized with strong written and verbal communication skills.

• Experience developing ADCs, DACs, or other targeted therapeutic modalities.
• Familiarity with linker-payload chemistry, site-specific conjugation, and cysteine-based conjugation strategies.
• Experience with analytical analysis of conjugates: DAR, aggregation, and stability of conjugates.
• Experience in synthetic organic chemistry, including the synthesis, purification, and characterization of small molecules and linker-payloads.

• None

The annual rate of pay for this position ranges from $86,100 - $131,300 for Scientist I and $95,900 - $146,300 for Scientist II. For non-exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company's discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company's benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.

The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this…