Nuclear Magnetic Resonance Spectroscopist (52245

Nuclear Magnetic Resonance Spectroscopist

National Institutes of Health (NIH) - Rockville Campus - Rockville, MD 20852

Salary Range $ - $ Salary/year Level Experienced Position Type Full Time Job Shift Day Education Level Ph.D. Travel Percentage None Category Public Health

Position Objective:
The Nuclear Magnetic Resonance (NMR) Spectroscopist contractor in the Analytical Chemistry Core (ACC), Division of Preclinical Innovation (DPI), NCATS, provides analytical chemistry support for translational research. The position requires expertise in solution-state NMR spectroscopy for small molecules and/or proteins. Responsibilities include operating and maintaining high-field NMR instruments; performing structural characterization, purity assessments, concentration and binding studies; developing new NMR methods;

preparing samples; troubleshooting instrumentation, including cryogen fills; analyzing and interpreting spectral data; and training staff in instrument operation and NMR applications.

Duties and Responsibilities:

• Provide support for the ACC NMR Spectroscopy laboratory, which includes the operation of four (4) 400 MHz spectrometers and one (1) 600 MHz spectrometer
• Perform general maintenance and upkeep of equipment and instrumentation.
• Perform instrument quality control to ensure proper function.
• Collect and review data; analyze and interpret data and results.
• Conduct and write literature reviews for current and future projects.
• Work with staff in identity, purity and stability analysis.
• Prepare samples of various modalities prior to NMR analysis
• Conduct various 1D, 2D, nD, and VT NMR experiments, as well as perform spectral analysis and interpretation for structure verification, conformational analysis, chromatographic and isotopic purity analysis, and impurity identification
• Perform weekly liquid nitrogen fills and quarterly helium fills of the NMR magnets
• Utilize in-house compound tracking system; enter and review data.
• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals. Prepare summaries, reports and presentations based on findings
• Perform both routine and specialized laboratory procedures of moderate to high complexity.
• Demonstrate and maintain current knowledge of NMR spectroscopy and associated instrumentation, providing subject matter expertise to internal and external collaborators.
• Assesses methods and procedures for use in experiments, and makes modifications and improvements to resolve problems and meet
• specific needs.
• Maintains accurate, detailed records of experiments, and evaluates and interprets results for validity and scientific meaning.
• Provide training to staff on the proper usage and maintenance of mass spectrometry instrumentation and equipment.
• Provide general and advanced training on mass spectrometry techniques, methods, and protocols.
• Train staff on the proper usage of NMR spectrometers for obtaining routine NMR spectra.
• Develop and document new procedures.
• Develop and implement novel methods and platforms for NMR sample preparation and analysis of various modalities, including small molecules, peptides, and proteins, utilizing automation and high-throughput technologies.
• Monitor and report on all safety issues.
• Ensure all raw NMR data are properly retained.
• Meet with lab members to present updates – Weekly
• Perform and document activities supporting nuclear magnetic resonance (NMR) spectroscopy operations, including instrument maintenance, liquid nitrogen and helium fills, equipment servicing and repair, sample preparation, data acquisition, processing, analysis, and spectral interpretation. Generates and organizes scientific data, figures, and tables; conducts literature reviews; prepares technical reports, manuscripts, presentations, posters, and operational manuals; and develops and refines analytical methods, procedures, workflows, and research platforms to support ongoing scientific and translational research programs.

Basic Qualifications:

• Ph.D. in Chemistry, Biophysics, or related discipline
• Direct experience with NMR spectrometers (Bruker, JEOL, and/or Agilent)
• Experience with saturation transfer…