Computational Protein Engineer
Job in
Rockville, Montgomery County, Maryland, 20849, USA
Listed on 2026-09-27
Listing for:
Job Juncture
Full Time
position Listed on 2026-09-27
Job specializations:
-
Research/Development
Biotech Research, Research Scientist, Biotechnology, Drug Discovery
Job Description & How to Apply Below
Our client is a leading biotech firm advancing innovative antibody and protein engineering programs.
They seek a Senior Scientist, Protein Engineering to lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.
The ideal candidate will take on the following responsibilities:
- Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
- Drive protein expression, purification, and characterization workflows across multiple formats
- Design and execute binding and functional assays to evaluate and iterate on engineered proteins
- Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
- Apply computational tools such as Alpha Fold and Rosetta to support and inform wet lab strategies
- Manage CRO partnerships including experimental design, vendor communication, and internal reporting
The ideal candidate will possess the following qualifications:
- PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience
- Hands-on expertise in protein expression, purification, and characterization
- Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
- Peer-reviewed publications and/or patents in antibody or protein engineering
- Familiarity with computational design tools (Alpha Fold, Rosetta, ProteinMPNN) a plus
- Proven ability to lead technical teams and manage complex, multi-faceted projects
- Outstanding written and verbal communication skills
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