General Engineering & Skilled Trade Project Manager

Principal Project Engineer – Life Sciences Capital Projects

Location:

St. Louis, MO (Onsite) Duration: 12-Month Contract (Potential Extension) Pay:
Competitive Hourly Rate (DOE)

This is an outstanding opportunity to lead critical work streams on a large-scale life sciences construction project supporting the expansion of pharmaceutical manufacturing operations. The ideal candidate will bring extensive experience managing capital projects within GMP-regulated facilities, including cleanroom design, construction, commissioning, and validation activities.

If you're a seasoned engineering professional with a strong mechanical, electrical, or process engineering background and thrive in complex pharmaceutical environments, we'd love to speak with you.

• Lead engineering work streams on large pharmaceutical capital projects from planning through project completion.
• Manage project scope, schedule, budget, and technical execution while ensuring successful project delivery.
• Partner with site leadership, engineering, construction, quality, and operations teams to drive timely project decisions.
• Coordinate contractors, engineering disciplines, and project stakeholders throughout all project phases.
• Review engineering drawings, specifications, construction submittals, RFIs, and technical documentation.
• Identify project risks and develop mitigation strategies while proactively resolving technical and construction issues.
• Support commissioning, qualification, and validation activities for GMP manufacturing facilities.
• Maintain strong communication with project stakeholders while driving accountability across cross-functional teams.
• Ensure projects comply with applicable cGMP regulations, engineering standards, and company procedures.
• Manage scope changes, project documentation, and engineering deliverables throughout the project lifecycle.

• Bachelor's degree in Mechanical, Electrical, Process, Chemical, or related Engineering discipline.
• 15+ years of experience managing capital engineering projects.
• Demonstrated experience supporting pharmaceutical or biotechnology manufacturing facilities.
• Experience with cleanroom design and construction, including classified Grade C/D manufacturing spaces.
• Experience executing brownfield expansion projects within operating manufacturing facilities is highly preferred.
• Strong knowledge of commissioning, qualification, and validation processes.
• Experience supporting construction execution, contractor management, RFIs, submittals, and field engineering.
• Strong understanding of cGMP regulations and pharmaceutical manufacturing standards.
• Ability to interpret engineering drawings, specifications, P&IDs, and construction documentation.
• Excellent leadership, communication, and stakeholder management skills.
• Proven ability to independently manage complex engineering work streams.
• Must be able to work onsite in St. Louis, MO Monday through Friday.

• Pharmaceutical facility expansions
• Sterile manufacturing environments
• Cleanroom construction and classified spaces
• Brownfield capital projects
• Commissioning & Startup
• IQ/OQ/PQ support
• Construction Management
• Contractor Coordination
• Risk Management
• Project Controls

Sirius Staffing is a nationally recognized recruiting and staffing firm specializing in Engineering, Technical, Scientific, and Professional talent. We partner with industry-leading organizations across the country, connecting exceptional professionals with exciting career opportunities.

Our recruiters are committed to providing a personalized experience while helping you find opportunities that align with your career goals.

Sirius Staffing is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, sexual orientation, or gender identity), national origin, age, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

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