Post Doctoral Fellow

Founded in 1818, Saint Louis University is one of the nation’s oldest and most prestigious Catholic universities. It has a campus in Madrid, Spain, and is recognized for world‑class academics, life‑changing research, compassionate health care, and a strong commitment to faith and service.

Saint Louis University School of Medicine, Department of Neurology.

Project

Title:

Unraveling the Mechanisms of Alcohol‑Induced Blood‑Brain Barrier Disruption: A Focus on Lipid Signaling and Endothelial Cells.

Position Summary:

Saint Louis University’s Department of Neurology invites applications for a Postdoctoral Research Fellow to join a multidisciplinary team working on an NIH‑funded project that investigates alcohol‑induced cerebrovascular dysfunction, focusing on the role of lipid signaling in blood‑brain barrier (BBB) disruption and neuroinflammation. The postdoctoral fellow will be involved in MCAO surgeries, biochemical analysis, and behavioral testing in a cutting‑edge research environment.

• Perform Middle Cerebral Artery Occlusion (MCAO) surgeries to model ischemic stroke in mice.
• Conduct biochemical assays to analyze lipid signaling, enzyme expression, and oxidative stress markers in brain tissue.
• Perform Western blotting, PCR, immunohistochemistry, and fluorescence imaging.
• Coordinate and execute behavioral studies to assess cognitive and motor deficits, including Morris Water Maze (MWM), Novel Object Recognition (NOR), and Fear Conditioning Tests (FCT).
• Collaborate with laboratory team members on experimental design, data analysis, and manuscript preparation.
• Contribute to grant writing and publication of research findings in peer‑reviewed journals.

• A PhD in Neuroscience, Neurobiology, or a related field.
• Experience in surgical techniques, specifically MCAO, for stroke models in mice.
• Strong background in biochemical assays, including Western blotting, PCR, and immunohistochemistry.
• Experience with behavioral analysis in mice.
• First‑author publication history in peer‑reviewed journals.
• Strong communication skills and ability to collaborate with a diverse team of researchers.

• Experience with lipid signaling, autotaxin, and LPP3 pathways in cerebrovascular research.
• Knowledge of animal models of neuroinflammation and ischemic stroke.
• Familiarity with neuroimaging techniques and data analysis tools (e.g., ImageJ, Graph Pad Prism).

• Location:
  
  Saint Louis University School of Medicine, Department of Neurology, St. Louis, MO.
• Full‑time, 40 hours/week.
• Compensation:
  Competitive salary with benefits.

Saint Louis University is an Equal Opportunity/Affirmative Action Employer. We encourage applications from individuals with disabilities, minorities, women, and veterans.