Post Doctoral Fellow

Postdoctoral Fellow – Computational Biology / Bioinformatics

Focus:
Multi-omics and Longitudinal Modeling in Alzheimer's Disease

Appointment:
Full-time, 1-year term (renewable pending funding and performance)

Position Overview

We are seeking a highly motivated postdoctoral fellow with a PhD in computational biology, bioinformatics, biostatistics, data science, or a related quantitative field to join an interdisciplinary research program focused on Alzheimer's disease (AD) and neurodegeneration.

The fellow will lead and contribute to advanced bioinformatics, multi-omics integration, and statistical modeling efforts using large, well-phenotyped longitudinal datasets (e.g., proteomics, transcriptomics, imaging, clinical, and biomarker data). The position is ideal for a candidate interested in mechanistic discovery, biomarker development, and translational neuroscience, with opportunities for high-impact publications and grant development.

Key Responsibilities

• Perform computational analysis of large-scale omics datasets, including proteomics, transcriptomics, and related modalities
• Integrate multi-omics data with clinical, cognitive, and imaging phenotypes in longitudinal cohorts
• Develop and apply statistical and machine-learning models (e.g., mixed-effects models, survival analysis, dimensionality reduction, clustering, trajectory modeling)
• Lead reproducible analysis pipelines in R, Python, or related frameworks
• Interpret results in biological and clinical context, with emphasis on Alzheimer's disease mechanisms and biomarkers
• Prepare figures, tables, and methods for peer-reviewed manuscripts and conference presentations
• Collaborate with clinicians, wet-lab scientists, and biostatisticians in an interdisciplinary environment
• Contribute to grant proposals and progress reports as appropriate
• Mentor graduate or undergraduate trainees in computational methods (optional, depending on interest)

Required Qualifications

• PhD in computational biology, bioinformatics, biostatistics, data science, systems biology, or a related quantitative discipline
• Strong experience with high-dimensional biological data analysis
• Proficiency in R and/or Python for statistical computing and data analysis
• Solid foundation in statistics and data modeling, particularly for longitudinal or cohort-based data
• Demonstrated ability to work independently and manage complex datasets
• Strong written and verbal communication skills in English
• Evidence of productivity (e.g., peer-reviewed publications, preprints, or advanced projects)

Preferred Qualifications

• Experience with longitudinal modeling (e.g., mixed-effects models, disease progression modeling)
• Familiarity with neurodegenerative disease research, Alzheimer's disease, or aging biology
• Experience with proteomics platforms (e.g., Olink, Soma Scan, mass spectrometry)
• Knowledge of multi-omics integration, network analysis, or pathway enrichment methods
• Experience working with large consortium datasets (e.g., ADNI, AMP-AD, UK Biobank, similar)
• Interest in translational research, biomarker discovery, or drug target identification
• Experience with reproducible research practices (version control, documentation, workflow tools)

Environment & Opportunities

The fellow will join a highly collaborative research environment at the interface of neurology, neuroscience, and computational biology, with access to rich datasets and strong clinical context. The position offers:

• Intellectual ownership of projects
• Opportunities for first-author publications
• Exposure to grant writing and translational research strategy
• Career mentorship tailored to academic, industry, or hybrid career paths

Term & Compensation

• One-year appointment with possibility of renewal based on funding and performance
• Competitive salary and benefits commensurate with experience and institutional guidelines

Application Instructions:

Applicants should submit:

• Curriculum vitae
• Brief cover letter describing research interests and relevant experience
• Contact information for 2–3 references

Grant-funded post-doctoral appointments may be terminated if grant funding ends.

This position does not currently sponsor J1, H1B, or O visas.

Function:
Research Support

Scheduled Weekly

Hours:

40

Saint Louis University is an equal opportunity/affirmative action employer. All qualified candidates will receive consideration for the position applied for without regard to race, color, religion, sex, age, national origin, disability, marital status, sexual orientation, military/veteran status, gender identity, or other non-merit factors. If accommodations are needed for completing the application and/or with the interviewing process, please contact Human Resources at .