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Radiochemist

Job in St. Louis, Saint Louis, St. Louis city, Missouri, 63105, USA
Listing for: Orchestra Life Sciences
Full Time position
Listed on 2026-08-04
Job specializations:
  • Science
    Biotech Research, Research Scientist
Salary/Wage Range or Industry Benchmark: 70000 - 110000 USD Yearly USD 70000.00 110000.00 YEAR
Job Description & How to Apply Below
Location: St. Louis

The Radiochemist will support multidisciplinary radiochemistry R&D and isotope production initiatives for TAG1, working closely with senior team members to develop and optimize Lead-212 (Pb-212) production using Radium-224 (Ra-224) generator systems, and support other projects in the company.

This role plays a critical part in advancing isotope production processes from early development through scale-up and GMP readiness, supporting the development of life-saving radiopharmaceuticals used in targeted alpha therapies.

This is a hands-on laboratory role requiring strong collaboration across cross-functional teams and a commitment to rigorous documentation, data integrity, and radiation safety practices in controlled and shielded environments.

Role Focus

As a Radiochemist, you will play a key role in isotope production projects involving production of radionuclides and radiolabeling of protein and peptides. Under the guidance of senior team members, you’ll act as a primary stakeholder for assigned project tasks, contributing to chemical separation workflows, documentation, and laboratory experiments.

Key Responsibilities
  • Generate and maintain development and GMP-aligned documentation, including SOPs, batch records, and experimental records with strong data integrity practices.
  • Support process scale-up, tech transfer, and GMP readiness activities, including collaboration with Quality and Engineering teams.
  • Participate in target material selection and target design for cyclotron-based radionuclide production.
  • Work closely with engineering teams to design, evaluate, and optimize fixtures, tools, and other equipment for improved hot-cell operations.
  • Develop, refine, and execute chemical separation and purification workflows, with emphasis on ion exchange and other radio chemical methods.
  • Collaborate with cross-functional teams including radiation physics, health physics, cyclotron operations, quality, engineering, and logistics.
  • Perform laboratory experiments, data collection, and analytical measurements to support R&D objectives.
  • Ensure full compliance with GMP, cGMP, ISO-based quality systems, and radiation safety requirements.
Qualifications & Experience
  • Bachelor's degree in Chemistry or related field with 2–5 years of relevant laboratory experience, or Master’s degree preferred. Must have wet lab experience in a chemistry laboratory setting.
  • Experience with separation chemistry; ion exchange chromatography strongly preferred.
  • Experience with radiolabeling of proteins and peptides.
  • Experience with spectroscopy techniques including IR, ICP-MS, gamma spectroscopy, UV-Vis, and familiarity or direct experience in radiochemistry, radioisotope production, or nuclear materials.
  • Experience working in controlled laboratory environments requiring strict documentation and understanding of GMP or GMP-like environments, including documentation expectations.
  • Ability to interpret workflow requirements and translate them into equipment lists, process steps, and technical specifications.
  • Strong documentation skills, comfortable drafting and revising SOPs and technical procedures.
  • Proficiency in Microsoft Office tools.
Preferred Experience
  • Experience or coursework in nuclear science, cyclotron systems, or radiation physics.
  • Familiarity with engineering drawings, CAD tools, or mechanical prototyping is a plus but not required.
  • Awareness of cGMP, and ISO quality systems.
  • Exposure to hot-cell operations or shielded environments is ideal.
Why Join Orchestra Life Sciences
  • Leadership role with significant organizational impact across multiple geographies.
  • Opportunity to shape construction strategy for cutting-edge GMP and cleanroom facilities.
  • Collaborative, science-first culture with strong leadership visibility.
  • Competitive compensation, benefits, and growth opportunities.
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