Bioinformatics Manager; Oncology Product Development

Bioinformatics Manager (Oncology Product Development)

Natera is seeking a Bioinformatics Manager to lead the Bioinformatics team focused on Oncology Product Development. The role involves managing a team of bioinformaticians and data scientists and providing technical leadership in the design, development and validation of ctDNA-based diagnostic tests. This position requires collaboration across biostatistics, molecular biology, software engineering and commercial departments. The ideal candidate will have strong bioinformatics and data science expertise, with experience in analysis or modeling of DNA methylation data and a track record of project and technical leadership.

• Lead the development, optimization, and improvement of tools and analysis pipelines for diagnostic tests, including detection of cancer-associated variants or methylation patterns and setting evidence-based quality control thresholds.
• Provide technical leadership for product development projects by representing the team in cross-functional interactions and advancing products from research through commercial launch.
• Supervise bioinformatics scientists and data scientists, manage technical contributions, prioritize resources, and develop team members.
• Provide input on experimental design, analysis and interpretation based on expertise in Natera’s technology and relevant mathematical principles.
• Operate with a high level of independence and responsibility in carrying out assignments.
• Contribute to the company’s intellectual property portfolio.
• Set standards for rigorous data analysis and lead the production of high-quality documentation.

• Minimum 4-8 years of postgraduate experience in a data science and/or bioinformatics role and 1-3 years as a technical lead in diagnostics or a related field.
• Experience moving algorithm-based products through commercialization and launch in medical or biological applications such as diagnostic testing, medical imaging, or biotechnology.

• Prior experience analyzing or modeling DNA methylation data (not required).

• Experience using Python or R for scientific data analysis and visualization.
• Strong foundation in statistical modeling and machine learning, including probability theory and estimation/classification methods.
• Experience with analysis of next-generation sequencing data, including algorithm development or optimization.
• Ability to apply mathematical principles to solve real estimation problems and implement practical solutions.
• Excellent analytical, problem-solving and decision-making skills to independently make sound judgments and develop creative solutions to moderately complex problems.
• Experience leading technical projects, defining and meeting milestones, delegating tasks, and ensuring quality of deliverables.
• Excellent communication skills and the ability to work in a dynamic and collaborative environment.

This range reflects a good-faith estimate of base pay at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is eligible for additional compensation and benefits through Natera’s Total Rewards program, including:

• Annual performance incentive bonus
• Long-term equity awards
• 401(k) with company match
• Generous paid time off and company holidays
• Wellness and work-life benefits

Compensation Range: $154,000 - $192,500 USD

Natera is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. We aim to make personalized genetic testing and diagnostics part of standard care to protect health and enable earlier and more targeted interventions.

Our team comprises statisticians, geneticists, doctors, laboratory scientists, software engineers and other professionals from world-class institutions who care deeply about our work and each other. You’ll be challenged and grow quickly while contributing to changing the landscape of genetic disease management.

Competitive benefits including comprehensive medical, dental, vision, life and disability plans for employees and dependents. We offer fertility care benefits, pregnancy and bonding leave, 401(k) with company match, commuter benefits, and an employee referral program. Equal opportunity employer statement and commitment to diversity and inclusion are provided.

We encourage all qualified applicants to apply. Final hiring decisions are made without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or other legally protected status.

Natera is an Equal Opportunity Employer. We value diversity and inclusive collaboration to advance our mission of changing the management of disease worldwide.