Scientist II to Director: Microbiome Discovery & Colonization

Scientist II to Director:
Microbiome Discovery & Colonization

Level and

Title:

Dependent on experience of applicant. This role is level-agnostic. We are hiring the right person across the Scientist–Director range and will calibrate title, level, and scope to prior experience.

Reports To:

Microbial Discovery Team Lead Company Size: ~23 employees Industry: Sustainable Agricultural Biotechnology

About Switch

Based in San Carlos, CA, Switch Bioworks is redefining bioproduction through programmable microbes. Beginning with agriculture, we are developing nitrogen-fixing microbial consortia that live directly on crop roots. This replaces expensive, carbon-intensive synthetic fertilizers with a living alternative that reshapes the economics and sustainability of farming.

Our edge lies in our namesake "switches" - synthetic biology control systems that activate microbial production only when and where it's needed. By combining microbial ecology with advanced genetic control systems, Switch is building a biological platform with the potential to transform agriculture and a wide range of industrial bioproduction applications.

Position Summary

You will own Switch's effort to discover, characterize, and deploy consortia of microbes that reliably establish in the host environment, starting with the corn root microbiome and building a platform extensible to other microbiomes over time.

Competitive colonization is a big challenge for the field, and advancing it is the central mandate of this role. We need a thought leader to design scientific programs that identify the variables that govern root colonization and systematically build consortia-assembly capability that combines bioinformatic and experimental evidence into confident strain-prioritization decisions.

We are looking for a hands-on scientific leader who pairs deep experimental microbiology with strong computational and data-science instincts. This is a senior individual-contributor role with people-leadership scope. You will be at the bench routinely designing, running, and troubleshooting experiments yourself and mentoring a small team directly or cross-functionally. You will build and mine a large microbial biobank as our discovery engine, run discovery and consortia assembly campaigns, establish rigorous quantitative colonization measurements, and partner closely with our engineering, field, and process teams to move winners toward the field.

Key Responsibilities

Colonization & Microbiome Performance: Define and hit quantitative colonization targets, starting with the corn root microbiome and expanding into new microbiome fields over time. Design and lead the scientific program to identify the governing variables and systematically build a consortia-assembly capability that integrates bioinformatic and experimental data.

Biobank Development: Build, curate, and mine a large, well-characterized microbial biobank spanning culturomics, structured metadata capture, and storage powered by automated, high-throughput workflows across isolation, phenotyping, and screening that scale strain characterization and compress discovery-to-prioritization cycle times. Establish documented provenance and chain of custody for every isolate from the point of collection to handoff to the engineering team.

Quantitative Microbiology & Data Science: Establish rigorous colonization quantification methods and own the translation of measurements from grow room/greenhouse systems into the field. Analyze complex sequencing and phenotyping datasets, and build reproducible bioinformatic and computational workflows that guide isolation, strain prioritization, and consortia design.

Consortia Design & Predictive Modeling: Design and assemble multi-strain consortia with manufacturing reality from the outset. Build predictive models that link strain traits and interactions to colonization and function initially optimized for corn roots, with a framework extensible to additional crops or different microbiome systems over time including the human gut microbiome.

Intellectual Property: Recognize patentable inventions as they emerge from the microbiome discovery efforts and contribute to invention disclosures.

Trial & Cross-functional Support: Partner with the engineering, field, and process teams to validate colonization; support growth chamber, greenhouse, and field studies with well-characterized materials and analysis.

Team & Mentorship: Support, mentor, and guide a small team of scientists and research associates through direct and indirect influence. Set day-to-day technical direction for the group, guide people development, contribute to headcount and spend planning, and manage project budgets and external services.

Characteristics of a Successful Candidate

Must be authorized to work full-time in the U.S. and able to work on-site daily in San Carlos, CA.

Deep experimental microbiology mastery, including microbial isolation, culturing, and plant-microbe colonization assays.

Computational and data-science fluency;…