Associate Scientist II, Immunoassay Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

• RETHINK CONVENTION:
  We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.
• AIM HIGH:
  We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
• LEAD WITH HEART:
  Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
• MODEL EXCELLENCE:
  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Vaxcyte is seeking an accomplished Associate Scientist II, Immunoassay Development to join the CMC Immunoassay group. This role will provide scientific and strategic leadership for the development, qualification, characterization, governance, and lifecycle management of critical reagents and reference materials that support immunoassays across Vaxcyte's vaccine pipeline. The Associate Scientist will work closely with scientists, senior scientists, and laboratory leaders to execute immunoassays, support fit-for-purpose method development, assist with troubleshooting studies, and contribute to high-quality laboratory documentation and data integrity.

• Perform hands-on assay execution to support immunoassay development, optimization, platform evaluation, routine testing, method transfer support, and under direct supervision, validation readiness, and lifecycle activities.
• Engage daily in laboratory operations, including reagent preparation, sample handling, plate or bead preparation, instrument operation, assay setup, data capture, documentation, and laboratory organization.
• Execute immunoassays supporting potency, antigenicity, identity, impurity, characterization, comparability, release, stability, and development-stage analytical needs.
• Support experiments using ELISA, MSD, bead-based assays, multiplex assays, electrochemiluminescence-based assays, or other ligand-binding assay formats.
• Prepare reagents, buffers, samples, plates, beads, assay controls, reference materials, and other materials required for immunoassay testing.
• Generate and summarize assay data, including standard curves, sample response, dilution response, recovery, precision, assay controls, and system suitability results.
• Under direction of a Scientist or Sr. Scientist, support troubleshooting studies by executing experiments, documenting observations, organizing data, and communicating findings to scientists and project leads.
• Support critical reagent and reference material activities, including aliquoting, labeling, inventory tracking, reagent screening, lot comparison, stability study support, and qualification-support testing.
• Maintain accurate and timely laboratory documentation, including ELN entries, assay worksheets, reagent records, sample records, and data summaries.
• Support laboratory readiness, including consumable tracking, instrument use coordination, sample tracking, safety compliance, and good laboratory practices.

• BS. in Biochemistry, Immunology, Analytical Chemistry, Biological Sciences, or a related discipline with a minimum of 2 years of relevant biopharmaceutical industry laboratory experience; or M.S. in a related discipline with minimum 1 year of relevant biopharmaceutical industry laboratory experience.
• Hands-on laboratory experience with immunoassays, ligand-binding assays, analytical testing, bioanalytical testing, or related…