Senior Scientist, Epithelial and Stromal Biology

General Description:

Candidates must be able to work onsite in San Carlos, California.

At BeOne Institute, We Extend BeOne’s Execution Strength With a Dedicated Innovation Engine, Bringing Agility And Scientific Depth To Transform Uncertainty Into Actionable And High-impact Therapeutic Opportunities. We Operate According To Three Core Principles:

• Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.

• Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision.

• Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

As a Senior Scientist at BeOne Institute, you will independently design and execute high-quality research studies supporting discovery and translational programs in immunology, inflammation, and immuno-oncology. You will contribute to target evaluation, mechanistic understanding, and therapeutic development through generation of rigorous, decision-enabling data packages.

• Identify and advance high-value therapeutic targets across immunology, inflammation and immuno-oncology therapeutic areas, aligned with organizational strategy, portfolio priorities and emerging scientific opportunities.

• Independently design, execute, analyze and interpret in vitro, ex vivo, and in vivo studies to validate target biology, establish disease rationale, evaluate therapeutic modalities, develop mechanistic insight, and generate decision-enabling data packages.

• Communicate progress through regular updates while proactively identifying challenges and proposing solutions.

• Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute.

• Contribute to management and operational activities to support strategic objectives of the BeOne Institute at the San Carlos site.

• May mentor junior scientists, research associates, interns

• Travel:
  No
• Ph.D., M.D., or equivalent advanced degree in one or more of the following areas : cancer biology, immuno-oncology, immunology, epithelial and stromal biology, stem cell biology or a related life sciences discipline. 2+ years of related experience.
• Demonstrated track record of scientific achievements, as evidenced by publications in high-impact journals.
• Demonstrated ability to design experiments, generate high-quality data, analyze complex datasets, and communicate scientific findings effectively.
• Hands‑on experience with relevant laboratory techniques such as primary human/mouse epithelial and stromal cell culture, air‑lift culture, epithelial organoid culture, cell line engineering, histology, IHC, IF, flow cytometry, ELISA, MSD, molecular biology methods, protein characterization, microscopy/high‑content imaging, or related experimental platforms.
• Experience with one or more of the following is preferred: in vitro and in vivo disease models, AI‑driven protein design, protein engineering, induced proximity technologies, synthetic biology approaches, or other innovative therapeutic platforms.
• Knowledge of biologics, small molecules and other complex modalities, experience with omics data analysis, and/or preclinical immunology and oncology mouse models is a plus.
• Ability to operate effectively in a highly collaborative, fast‑paced, and interdisciplinary research environment, and to integrate multi‑disciplinary approaches to solve complex biological problems.
• Strong collaboration skills across functional and disciplinary boundaries.
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non‑technical audiences.

Ph.D., M.D., or equivalent advanced degree

No

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.