Sr. Scientist - mRNA Purification and Analytical Chemist

Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and are looking for people who are determined to make life better for people around the world.

The Biotechnology Discovery Research group is located in both San Diego and Indianapolis. It discovers medicines that address significant unmet needs by integrating biology with innovative scientific capabilities in protein discovery, production and characterization, and engineering. We collaborate with colleagues in both the discovery and development organizations, including scientists in therapeutic area biology, biomolecule formulation and develop ability, ADME, Toxicology, PK/PD, Statistics, Computational Sciences, Clinical Development, and more.

Our team has more than 25 years of experience discovering and developing antibodies, proteins, and peptide therapeutics.

We are looking for a motivated associate scientist with a strong background in mRNA purification and analytical characterization to be part of the in-vivo CAR-T therapeutics matrix team. This role offers an opportunity to apply advanced expertise in mRNA process development and analytical QC to advance our biotherapeutic discovery portfolio.

If you are a highly motivated teammate with a passion for goal-oriented scientific research and a background in mRNA/oligonucleotide chemistry, we urge you to join the Lilly Team today!

• Design and conduct experiments to optimize mRNA purification protocols using various chromatography techniques to enhance yield and purity.
• Perform and optimize analytical QC assays (HPLC/UPLC, capillary electrophoresis, gel electrophoresis) to characterize and quantify mRNA.
• Establish high-throughput mRNA purification and analytical QC workflows for screening purposes, leveraging automation capabilities.
• Analyze experimental data, prepare comprehensive technical reports and protocols, and present findings to multidisciplinary teams.

• Bachelor's or Master's degree in chemistry, biochemistry, biotechnology, bioengineering, biophysics, or related field with 5 years (Bachelor's) or 3 years (Master's) of relevant industry experience.
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

• Extensive hands-on experience with nucleic acid/mRNA purification, QC and advanced analytical characterization.
• Expert-level proficiency operating AKTA, Agilent HPLC and Open Lab software.
• Experience establishing and optimizing high-throughput oligonucleotide/mRNA workflows.
• Proven ability to analyze large datasets.
• Experience in protein purification and analytical characterization is a plus.
• Knowledge of in vivo CAR-T and mRNA therapeutics is beneficial.
• Excellent communication skills with the ability to prioritize and meet deadlines.
• Team player with strong organizational skills ready to work effectively with cross-functional colleagues in a collaborative, fast-paced environment.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks and are open to all employees. Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 - $187,000. Full-time equivalent employees are eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefits program including (but not limited to) a 401(k); pension; vacation benefits; medical, dental, vision and prescription drug benefits;

flexible spending accounts; life insurance; time off and leave benefits; and well-being benefits.

Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs at its discretion. #We Are Lilly