SAP Principal Enterprise Architect, S​/HANA & Digital Platforms

Position: SAP Principal Enterprise Architect, S/4HANA & Digital Platforms
What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Location - Please Read Before Applying

San Diego HQ - Hybrid.

Must currently reside in the San Diego metropolitan area or be able to commute independently.

This role will require being onsite for all workshops, which will be extensive.

Position Summary

The SAP S/4

HANA & Digital Platforms Enterprise Architect provides strategic and hands-on architectural leadership for enterprise-wide digital transformation initiatives, with SAP S/4

HANA as the digital core
, integrated with best-of-breed platforms such as Salesforce (SFDC), MES, LIMS, Vertex, SAP VIM, and other ERP and non-ERP systems.

This role is responsible for defining the future-state enterprise architecture, governing solution design, and ensuring alignment between business strategy, process design, data, integration, security, and technology platforms. Success in this role requires equal strength in technical architecture, stakeholder partnership, and influence-based leadership across business and IT.

Key Responsibilities
1. Enterprise Architecture & Strategy Leadership

• Own and evolve enterprise architecture vision, principles, standards, and roadmaps across business, application, data, and technology domains
• Develop future-state architecture and associated transition roadmaps aligned with business growth objectives
• Serve as a trusted advisor to business and IT leadership on architectural trade-offs, sequencing, and investment decisions
• Lead and participate in architecture governance forums (Design Authority, Architecture Review Boards)

2. SAP S/4

HANA as the Digital Core

• Define and govern SAP S/4
  
  HANA target-state architecture as the enterprise ERP backbone
• Enforce clean-core principles
  , extensibility strategies (in-app vs side-by-side), and SAP best practices
• Provide architectural guidance across SAP domains including Finance, Sales, Supply Chain, Manufacturing, Quality, EAM, and EHS
• Build and maintain the ERP strategy and roadmap
  , including ECC-to-S/4 or multi-ERP coexistence scenarios

3. Boundary Systems & Ecosystem Architecture

• Provide architectural oversight and integration strategy for enterprise platforms, including but not limited to:
• Salesforce (SFDC) - CRM, Service, CPQ, Order-to-Cash integrations
• Manufacturing Execution Systems (MES) - shop-floor execution, material consumption, genealogy
• Laboratory Information Management Systems (LIMS) - quality, compliance, lab workflows
• Vertex - tax calculation and compliance
• SAP VIM - invoice automation and document management
• Legacy, regional, or niche ERPs during coexistence or transition

Ensure:

• Clear system-of-record ownership
• Scalable and resilient integration patterns
• Data consistency, reconciliation, and error-handling strategies

4. Integration, Data & Reporting Architecture

• Define enterprise integration strategy (API-led, event-driven, middleware-based)
• Govern integration platforms such as SAP BTP, CPI, Mule Soft
  , or equivalent
• Lead ERP-related integration rationalization and optimization
• Define master data ownership
  , governance models, and reporting strategies (real-time vs operational)
• Ensure alignment with analytics, AI/ML, and data platform needs (e.g., data lakes)

5. Solution Delivery & Transformation Enablement

• Partner with PMO, delivery leads, and system integrators across Design, Build, Test, and Deploy
• Review and approve solution artifacts (HLDs, FSDs, TSDs, integration and security designs)
• Establish and promote business capability models linking strategy, processes, systems, and data
• Identify architectural risks early and recommend…