Principal Cloud Engineer, Infrastructure | Onsite San Diego HQ

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company dedicated to discovering, developing, and commercializing life‑changing treatments for patients with under‑addressed neurological, psychiatric, endocrine, and immunological disorders. The company focuses on addressing complex conditions and advancing therapeutic areas with multiple FDA‑approved treatments and a robust pipeline of mid‑to‑late phase clinical candidates.

The Principal Cloud and Infrastructure Engineer is a senior technical expert responsible for designing, modernizing, and optimizing enterprise‑scale hybrid cloud environments across Azure, AWS, and on‑prem infrastructure. The role leads cloud transformation initiatives—migration, automation, infrastructure modernization, Fin Ops optimization, and secure platform engineering—while establishing architectural standards for scalability, reliability, compliance, and operational excellence.

• Lead enterprise‑scale cloud transformation initiatives, including infrastructure consolidation, virtualization, hybrid cloud modernization, and migration strategies across Azure, AWS, and on‑prem environments.
• Architect scalable, resilient, and highly available cloud infrastructure solutions aligned with business, security, and compliance requirements.
• Design and implement hybrid connectivity architectures leveraging Azure Express Route, VPN, SD‑WAN, private endpoints, and secure access technologies.
• Develop disaster recovery, business continuity, and high‑availability strategies across cloud and datacenter platforms.

• Champion automation‑first engineering practices using Infrastructure as Code (IaC) technologies including Terraform, ARM/Bicep, and Cloud Formation.
• Design and implement API‑driven, self‑service infrastructure provisioning platforms integrated with Service Now, identity platforms, and CI/CD pipelines.
• Standardize and automate infrastructure deployment, configuration management, patching, monitoring, and lifecycle operations.
• Lead adoption of modern platform engineering practices supporting scalable and repeatable infrastructure delivery.

• Lead cloud governance, cost optimization, and Fin Ops initiatives across Azure and AWS environments, including consumption analysis, reserved instance strategies, rightsizing, and budgeting controls.
• Establish operational standards for monitoring, observability, performance tuning, and incident response across hybrid infrastructure.
• Optimize storage and compute utilization through lifecycle management, automated tiering, and workload balancing strategies.
• Drive continuous improvement initiatives to enhance reliability, scalability, operational efficiency, and service performance.

• Architect and optimize VMware infrastructure platforms with a focus on footprint reduction, operational efficiency, resiliency, and automation.
• Design scalable enterprise storage solutions across Azure, AWS (S3, FSx), and Net App environments, including backup, replication, and lifecycle governance.
• Enable secure, scalable compute platforms supporting containerized workloads, Kubernetes orchestration, analytics platforms, and modern application hosting requirements.

• Implement identity‑driven access models using Active Directory, Azure AD/Entra , RBAC, and policy‑based provisioning frameworks.
• Integrate security best practices into all cloud and infrastructure architectures, including zero‑trust principles, segmentation, encryption, and secure access controls.
• Ensure compliance with enterprise security, audit, and regulatory standards across cloud and on‑prem environments.
• Collaborate with cybersecurity teams to implement governance policies, risk mitigation controls, and infrastructure hardening standards.

• Provide technical leadership, mentorship, and strategic guidance to cloud and infrastructure engineering teams.
• Partner with application, security, networking, and enterprise architecture teams to deliver scalable…