Director Translational Research; On site

Position: Director Translational Research (On site)
We are seeking a highly motivated and scientifically rigorous Director of Translational Research to lead translational strategy and execution for our pipeline. This individual will be responsible for identifying and validating development opportunities across multiple disease areas; planning and performing proof-of-concept studies in preclinical in vitro and in vivo models; developing and implementing potential predictive biomarkers for clinical hypothesis testing and patient selection;

and developing and implementing pharmacodynamic biomarkers for Neomorph's clinical studies.

The role is highly cross-functional and will work closely with Research Biology, Clinical Development/Clinical Operations, Data Sciences (Bioinformatics), and external collaborators/CROs. The ideal candidate has deep biology expertise in human disease biology, strong translational research experience, and the ability to operate effectively in a fast-paced, small-company environment.

Key Responsibilities

* Identify and validate development opportunities across the Neomorph pipeline.

* Design and oversee preclinical translational studies using in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling platforms.

* Develop predictive biomarker hypotheses and translational plans to support indication selection, patient enrichment, and resistance mechanisms.

* Developing and implementing pharmacodynamic biomarkers in Neomorph's clinical studies. Clinical biomarker strategies include tissue and blood-based assays, e.g., LC-MS, IHC/IF, ctDNA, NGS, and other potential biomarker readouts.

* Lead translational research strategy from discovery through early clinical development.

* Partner with Clinical Development/Operations to integrate translational endpoints into Phase 1/2 clinical protocols and to implement biospecimen collection, processing, shipment, testing, and data delivery.

* Oversee external vendors, academic collaborators, and CROs for translational assays and biomarker test development, validation, and analyses.

* Collaborate with Bioinformatics/Biometrics to analyze and interpret translational datasets, including genomics, transcriptomics, proteomics, pharmacodynamic, and clinical outcome data.

* Support dose selection, dose schedule optimization, indication expansion, and combination strategies through translational data.

* Contribute to regulatory documents, including INDs, clinical protocols, investigator brochures, annual reports, and responses to health authority questions.

* Present translational data and strategy to internal leadership and external partners.

* Stay current with the target's biology, biomarker technologies, competitive intelligence, and emerging therapeutic mechanisms.

Qualifications

* PhD, MD, MD/PhD, Pharm

D, or equivalent advanced degree in biology or genomics, molecular biology, translational medicine, or a related discipline.

* 10+ years of relevant experience in drug discovery, translational research, and clinical biomarker development, with biotech/pharma experience preferred.

* Experience supporting programs in IND-enabling, Phase 1, and/or Phase 2 clinical development.

* Experience with in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling.

* Hands-on experience with biomarker assays such as e.g., LC-MS, IHC, IF, ctDNA, NGS, RNA-seq, flow cytometry, proteomics, single-cell methods, etc.

* Demonstrated ability to translate preclinical biology into clinical biomarker and patient-selection strategies.

* Experience managing CROs, academic collaborations, and external translational vendors.

* Strong data interpretation skills and ability to integrate complex biological, pharmacodynamic, and clinical datasets.

* Excellent written and verbal communication skills.

* Ability to work independently, prioritize effectively, and thrive in a, fast-moving biotech environment.

Preferred Experience

* Experience in oncology and at least one non-oncology disease area is a plus.

* Experience with targeted protein degradation is a plus.

* Experience with PD biomarker…