Clinical Data Engineer II​/III

Clear Note Health is an early cancer detection company focused on the development and commercialization of non-invasive epigenomic tests to detect cancer through a standard blood draw, earlier than existing methods and when the disease is still treatable. Leveraging its novel liquid biopsy technology, Clear Note Health is initially focused on high-mortality cancers with the greatest need for early detection, starting with pancreatic and ovarian cancers.

The Clinical Data  Engineer II/IIIownsclinical Data Operations:thedatapipelines, data warehouse, and reporting infrastructure that transformclinical data,laboratorydata,and sequencing results into validated, audit-ready clinical and business data. Thispositionoperatesina regulated environment in which accuracy and traceability are as important as well-architected code. The role combines hands-on pipeline and data-modeling work with ongoing production data support for our clinical studyoperations andis central to the integrity of the data that informs our research and clinical decisions.

• Build andmaintainELT pipelines from clinical source systems — and non-standard sources such as ad hoc spreadsheets — into ourdata warehouse, and design ingestion frameworks that adapt to evolving report formats
• Support bulk data transfer initiatives to external partners and client-facing destinations, including the definition of the data contracts those partners depend on
• Develop, test, and refactor data transformation models across core clinical schemas, implementing precise, well-specified business logic, and integrate clinical data with other corporate data
• Define methods and metrics for assessing data quality, and monitor andmaintaindata quality across clinical datasets
• Own the reliability of clinical result data end to end, tracing issues to their root cause and strengthening controls through documented change management
• Strengthen the resilience of data contracts and design reconciliation logic that unifies data from multiple sources into a single, authoritative record
• Serve as a trusted partner to clinical and laboratory operations and external stakeholders, resolving data questions and improving accuracy at the source
• Build andmaintaindashboards and monitoring, including those subject to formal system validation, and support the data needs of adjacent business systems
• Partner with the Regulatory/QA team to ensure clinical data flow and the data warehouse remain compliant with procedural and regulatory requirements
• Serve as a subject-matter expert on warehouse clinical data, providing technical guidance and training to research and development teams
• Provide project status updates to cross-functional stakeholders

• 5+ years of hands-on data engineering experience with production data-transformation frameworks (dbtpreferred) and a cloud data warehouse
• Software-engineering fundamentals and an expert understanding of database and data-warehouse concepts
• Deep SQL expertise, including the ability toidentifysubtle logic errors in complex queries
• Experience with ELT and data-integration tools
• Experience with designing,buildingandusingcontainers
• Proficiency in Python or a comparable scripting language
• Familiarity with cloud identity and access-management concepts (key-pair authentication, OAuth/OIDC, workload identity federation)
• Proven ability to work in a regulated environment, including precise documentation, change-control processes, and audit trails
• Enjoys a role that balances building new data systems with keeping production systems reliable and trusted
• Strong written and verbal communication skills, witha track recordof documenting your work
• Working knowledge of clinical or laboratory data systems is a plus
• Familiarity with clinical data standards (CDASH/CDISC) preferred
• Working knowledge of Good Clinical Practice (GCP) and the clinical trial process preferred
• Familiarity with cancer-related medical classifications and ontologies (e.g., ICD-10) a plus

On-site is preferred for this position, in either our San Diego or San Mateo office. Theanticipatedsalary range for this position is $150,000 - $190,000. The actual salary will be…