Vice President, Project Management - RayzeBio

Overview

Rayze Bio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company focuses on improving survival of people with cancer by harnessing the power of targeted radioisotopes. Rayze Bio operates as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS.

Rayze Bio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ
101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Rayze Bio has a leading radiopharmaceuticals pipeline with novel assets targeting HCC, RCC and Prostate cancer amongst others. Led by a successful and experienced entrepreneurial team, Rayze Bio aims to be the global leader in radiopharmaceuticals.

Leadership & Strategy

• Provide strategic direction and leadership for the program management organization, ensuring alignment with Rayze Bio's objectives and pipeline priorities.
• Lead the program management for the NDA filing of our first asset (Player and coach required).
• Build industry-leading asset and portfolio management capability across drug development to drive pipeline execution.
• Influence asset and portfolio decisions by identifying interdependencies and downstream implications across research, clinical, regulatory, medical, and commercialization.
• Guide decision-making in the context of building portfolio value versus solely progression of individual assets.

Team Management

• Lead, mentor, and develop a high-performing project management organization across early and late drug development as a centralized capability.
• Drive portfolio excellence through standardized operating practices across therapeutic areas, fostering a culture of excellence and continuous improvement.
• Serve as process owner of asset progression across governance checkpoints from first-in-human through registration and submission.
• Mentor and guide talent development, including succession planning, performance management, and recognition.
• Enable cross-TA talent development opportunities to build a pipeline of program management talent across Rayze Bio and the broader BMS portfolio.

Portfolio Operations & Risk Management

• Lead global program team objective management, integrated portfolio operations, portfolio health, risk management, and portfolio prioritization.
• Partner with therapeutic area leadership, Global Program Leads (GPL's), commercial, business insights, and technology functions to ensure portfolio alignment.
• Maintain oversight of portfolio health and proactively identify and escalate systemic issues requiring portfolio or enterprise-level action.
• Design and lead initiatives to improve tools and processes for strategic planning and operations, specifically leveraging AI to simplify and eliminate low value human effort where possible and create competitive advantage via rate of program execution
• Drive planning excellence, including implementation of enterprise planning tools (e.g., e-plan).
• Establish and monitor key performance indicators (KPIs) to track project progress.
• Use metrics to drive accountability and continuous improvement.
• Ensure all projects comply with regulatory requirements and industry standards.
• Maintain governance discipline across all stages of drug development.

Project Oversight

• Oversee planning, execution, and delivery of early and late drug development programs.
• Ensure programs are completed on time, within scope, and within budget.

Stakeholder Engagement

• Collaborate with internal and external stakeholders, including executive leadership in research, development, regulatory, safety, biometrics, data sciences, clinical, product development, commercial, and medical.
• Ensure alignment and success for jointly developed projects by coordinating closely with strategic alliance partners.
• Work closely with GPL's (Global Program Leads) to facilitate appropriate decision making aligned with a biotech mindset.

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