Scientist​/Senior Scientist, Bioanalysis - Ligand Binding Assays

Scientist / Senior Scientist, Bioanalysis - Ligand Binding Assays page is loaded## Scientist / Senior Scientist, Bioanalysis - Ligand Binding Assays remote type:
On-Site locations:
US CA San Diegotime type:
Full time posted on:
Posted Yesterday job requisition :
R6501##

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.##

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis  and uterine fibroids,  as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas.

For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit , and follow the company on ,  and . (
* in collaboration with Abb Vie*)##

About the Role:

We are seeking a highly motivated Scientist or Senior Scientist to join the Bioanalysis group with a strong preclinical focus, supporting early-stage biologics drug development programs. The primary responsibility of this role is ligand binding assay (LBA) development and bioanalysis for preclinical pharmacokinetic (PK) studies in rodents and non-human primates, primarily under non-regulated conditions. The position may also support regulated GLP toxicology studies and involve interaction with external CRO partners for method transfer and study execution.

Experience with ADA assay development is desirable and would be considered an add-on to the primary PK-focused responsibilities. ## Your Contributions (include, but are not limited to):
* Develop, optimize, and qualify ligand binding assays (e.g., ELISA, MSD/ECL, Gyrolab) to support preclinical non-regulated PK studies of antibodies, bispecifics, and fusion proteins in rodents and monkeys
* Perform hands-on bioanalysis of preclinical samples and ensure data quality, integrity, and scientific rigor
* Author and review bioanalytical protocols, assay qualification/validation reports, and preclinical study reports
* Analyze, interpret, and clearly communicate PK bioanalytical data to project and DMPK teams
* Collaborate closely with DMPK, toxicology, and pharmacology groups to support study design and data interpretation
* Interact with external CROs, including:  + Supporting assay and method transfer  + Providing technical oversight during outsourced studies  + Reviewing CRO data, reports, and study documentation
* Troubleshoot assay issues and continuously improve assay performance and workflows
* ADA assay development and support (screening/confirmatory/titer) may be involved on selected programs and is considered a desirable add-on to the primary PK role
* At the Senior Scientist level: provide technical leadership, mentor junior scientists, and contribute to preclinical bioanalytical and outsourcing strategy## Requirements:

Scientist
* BS/BA degree with 2+ years of industry experience in bioanalysis OR
* MS/MA degree and some experience as noted above OR
* PhD or equivalent and some experience as noted above
* Hands-on experience with ligand binding assay development for PK bioanalysis
* Experience supporting preclinical non-regulated studies, preferably in rodents and/or non-human primates
* Basic understanding of GLP principles and bioanalytical best practices
* Strong experimental, data analysis, and documentation skills

Senior Scientist
* BS/BA degree with 5+ years of industry experience in bioanalysis OR
* MS/MA degree and 3+ years of experience as noted above OR
* PhD or equivalent and some experience as noted above
* Demonstrated expertise in preclinical PK LBA strategy and execution
* Experience supporting GLP toxicology studies and working with quality/compliance functions
* Proven experience interacting with and overseeing external CROs
* Ability to work independently, lead bioanalytical efforts, and mentor junior scientists#LI-DM1

Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or…