Associate Scientist - Oncology In Vivo Pharmacology - San Diego, CA

Job Description

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Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post.

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

The Protein Homeostasis Thematic Research Center (TRC) at BMS is a fundamental Oncology research engine delivering oncology and hematology therapeutics to patients. The TRC has a major focus on exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable.

The Pharmacology group within the Protein Homeostasis TRC at BMS San Diego provides in vivo pharmacology support to discovery teams focused on developing small molecules and biologics for oncology and immune-oncology. As an integral part of discovery programs, the group supports lead identification through in vivo model screening and mechanism-of-action studies, develops and validates animal disease models, identifies pathway biomarkers, and establishes clinically relevant endpoints to assess efficacy.

Collaboration with DMPK, Exploratory Toxicology, and Translational Development is central to our work, and we contribute preclinical data to inform clinical development plans.

We are seeking a motivated Associate Scientist with broad experience in pharmacology and drug discovery for both small and large molecules. The successful candidate will work collaboratively in a multidisciplinary environment, taking responsibility for experiment design, planning, and execution. Key duties include interpreting and presenting in vivo data, conducting sample and endpoint analyses (ELISA, Western blot, Jess, qPCR, IHC), and preparing protocols and reports.

The role requires independent work, technical expertise, and contributions to project decisions. Strong communication, self-motivation, innovation, flexibility, and teamwork are essential.

• Develop disease models for oncology and immune-oncology
• Independently design and execute in vivo efficacy and PK/PD experiments to identify drug candidates
• Analyze and interpret data accurately, reporting findings to supervisors and colleagues
• Troubleshoot routine issues and recommend solutions
• Evaluate endpoints from in vivo studies using Western blots, mesoscale, qPCR, etc.
• Write precise protocols and technical reports
• Present data to multidisciplinary discovery teams
• Collaborate with cross-functional team members

Bachelor’s Degree

• Bachelor’s Degree
• 2+ years of academic and/or industry experience

• Bachelor's Degree and 2+ years of academic and/or industry experience with oncology models
• Experience in mammalian cell culture
• Experience in the development of syngeneic and xenograft cancer…