Associate Scientist, Scientist I​/II mRNA platform process development

Overview

The role

We are seeking a highly motivated Associate, or Sr. Associate, Scientist to work in a fast-paced PD environment applying rigorous scientific principles towards developing a platform process for producing mRNA. This role will play a critical part in developing, optimizing mRNA manufacturing process for lipid nanoparticle drug product development.

• Produce, purify, and characterize mRNA molecules to enable LNP drug product development.
• Use recombinant enzymes to produce and functionalize mRNA, AKTA systems to purify mRNA via affinity and other chromatography methods, TFF to further purify and formulate mRNA, and use HPLCs and other biochemical analytical techniques for characterization.
• An outstanding candidate will be driven by a desire to create, optimize, and define processes with speed in a collaborative environment.
• Material generation of purified mRNA.
• Execute and troubleshoot IVT and downstream process development and scaling-up experiments.
• Manage the flow of samples and data with various downstream users of mRNA.
• Assist in the design of experiments and interpretation of data.
• Actively participate and support lab maintenance and continuous improvement initiatives.
• Maintain accurate and detailed laboratory notebook and documentation.
• Summarize and present data in group meetings and contribute to group discussions.
• Author technical reports, study memos, and protocols.

• Scientist, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 2+ years relevant experience; OR MS with 3+ years; OR BS with 5+ years.
• Associate scientist, MS in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 1+ years relevant experience; OR BS with 3+ years.
• Hands-on experience with the downstream purification of biological molecules (AKTA, chromatography, TFF, viral filtration, etc.).
• Experience with molecular cloning, PAGE, and agarose gels.
• Experience working with, storing, and analyzing purified nucleic acids.
• Independently motivated with the ability to work in teams.
• Ability to communicate clearly and concisely through oral presentation and technical writing.
• Ability to leverage literature, internal and external resources to solve problems and develop new technologies.

• What We Offer:
  
  Opportunity to work at the forefront of nucleic acid science.
• Collaborative, science-driven culture with high impact research.
• Competitive compensation and benefits package, including health, dental, vision, and life insurance.
• 401(k) with company match.