Scientist II, Non-Viral Nanomedicine

The Position

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come.

Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group!

The Opportunity

We are seeking a highly motivated and skilled Scientist II to join the Nanotechnology Formulations group. This role will support our exciting non-viral nucleic acid delivery programs. The successful candidate will have high attention to detail and possess expertise in lipid nanoparticle (LNP) formulation process, formulation optimization for nucleic acid delivery, and basic LNP characterization skills.

Key Responsibilities

• Work under the direction of formulation scientists to synthesize and characterize lipid nanoparticles (LNPs) encapsulating nucleic acids for in vitro/in vivo studies.
• Carry out Design of Experiment (DoE) based screening campaigns directed toward establishing LNP composition or process.
• Support and execute early formulation development activities (cryoprotection, scale-up, etc.) for lipid nanoparticles.
• Interface directly with other functional teams to support formulation requests.
• Maintain detailed records documenting formulation activities and results.
• Analyze and interpret experimental data.
• Share responsibility for basic lab management activities (supply ordering, autoclaving, routine buffer preparation, etc.)

Who You Are

Required Qualifications

• B.S. with 3+ years of industry experience or M.S. with 2+ years of experience (an equivalent combination of education and experience may be considered).
• Formulation experience: 2+ years of hands-on laboratory experience with lipid nanoparticle formulation work.
• Experience utilizing analytical methods such as dynamic light scattering (DLS), Zeta potential measurement, and Ribogreen quantification of encapsulated nucleic acids.
• Experience with advanced analytical software (Graph Pad Prism and/or JMP).
• Excellent communication and organization skills.

Preferred/Growth Skills

• Prior experience with conjugated LNPs and high-throughput LNP formulation preparation is preferred but not required.
• Prior experience in tangential flow filtration (TFF) and formulation scale up is preferred but not required.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of San Diego, CA is $74,300 - $138,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.