Senior Research Associate; Temporary – In Vivo Pharmacology

About Tentarix

Tentarix Biotherapeutics is a biotechnology company with a revolutionary platform for the discovery of next generation, multispecific biologic drugs, with the potential to make a significant difference in the lives of patients suffering with diseases, such as cancer and autoimmunity. We are led by a seasoned executive team with proven expertise in the field of multispecific drug discovery, drug development, and company-building.

We are supported by top tier healthcare investors and have several ongoing partnered programs with Gilead and Abb Vie. We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape. This role will start as a six-month placement, with the potential to extend the term.

The Tentarix culture is founded on integrity, accountability, teamwork, and respect. Our team members are creative, hands-on, self-directed, and determined. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our team.

The Senior Research Associate will be primarily responsible for executing in vivo studies evaluating the activity of engineered protein therapeutics in numerous Immuno-Oncology and Autoimmune disease models. Additional responsibilities include assessments of pharmacokinetic and pharmacodynamic aspects of biotherapeutics. There will also be an opportunity to contribute to in vitro studies for evaluating the activity of engineered protein therapeutics.

• Responsible for the development and execution of a range of Pharmacology studies including PK/PD assays, disease models for immuno-oncology, autoimmune diseases such as tumor growth inhibition studies in humanized NSG tumor mice and autoimmune mouse models respectively.
• Additionally, there will be opportunities to learn and contribute to a series of in vitro and ex vivo bioassays such as MSD, ELISAs, engraftment check using flow cytometry, cell-based biological assays, immune cell bioassays.
• Independently design and execute experiments, analyze results, make presentations, and present data in group meetings.
• Maintain a meticulous record of protocols, data, and results.

• M.S./B.S./B.A. with 2-6+ years of industry experience in the field of immuno-oncology, autoimmune diseases, or other inflammatory diseases.
• Experience with animal handling and basic in vivo procedures of dosing, such as injections with various routes (s.c., i.p., i.v.), bleeding (tail bleed, cheek bleed, Retro Orbital), tumor measurement and collection of various organs for necroscopy for toxicology studies is required.
• Experience with in vivo cancer or autoimmune disease models is also required.
• Experience with cell culture including the culture of immune cells and tumor cells is desired.
• Technical experience in the development and execution of ELISAs, MSD, flow-cytometry, in vitro and ex vivo immunology assays, and/or in vivo pharmacodynamics and pharmacokinetic assays is a plus, but candidate can also be trained.
• Thrive in a cross functional team environment and committed positively contributing to Tentarix’s supportive small company culture.
• Trustworthy with highest integrity, committed to ethics and scientific standards.
• Excellent verbal and written communication skills.

The wage range for this role takes into account the wide range of factors that are considered in making compensation decisions including, but not limited to, skill sets, experience, training, licensure, certifications, and other business and organizational needs. The disclosed range estimate has not been adjusted for the applicable geographic differential associated with the location at which the position may be filled.

At Tentarix, it is not typical for an individual to be hired at or near the top of the range for their role and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current range for the hourly rate is $50 - $65 hourly.

Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Applicants must be currently authorized to work in the United States on a full-time basis. Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.

We are an E-Verify employer.