Associate Scientist - Molecular Discovery

Associate Scientist - Molecular Discovery

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals. Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

Pfizer Bio Medicine Design group at San Diego, CA is seeking an outstanding and highly motivated Associate Scientist with training in protein biochemistry to join a dynamic team in antibody discovery, optimization, and production. This role requires good understanding and hands-on skills in protein/antibody production and engineering.

• Work within a team on various antibody identification, optimization, and/or production projects in parallel.
• Maintain mammalian cell culture and execute various transient expression methods.
• Implement molecular biology methods such as reformatting scFv to IgG and other modalities.
• Implement protein purification methods to isolate IgG, fusion proteins and antigens from mammalian cell culture.
• Design experiments, analyze data, and troubleshoot when issues arise, under supervision.
• Present experimental design and results at internal meetings.
• Accomplish goals under project team timelines.

• B.S or M.S in Biological Science (Molecular Biology, Structural Biology, Biochemistry, Cell Biology) or a related field (Chemistry, Chemical Engineering, Biomedical Engineering and Biological Engineering)
• B.S or M.S with 0-2 years of relevant experience in either an academic or industrial setting.
• Familiar with tissue-culture sterile techniques and mammalian cell culture.
• Understand principles and able to execute modern molecular biology techniques, preferred in antibody engineering field.
• Understand principles and able to execute modern protein purification techniques, preferred in antibody engineering field.
• Detail-oriented, document data and experiments properly, good communication and interpersonal skills.
• Ability and desire to work in a fast-paced interdisciplinary scientific team and the desire to learn new techniques.
• Strong time management skills and ability to manage multiple projects at the same time.

• Previous experience with protein and/or antibody engineering
• Previous experience with suspension mammalian cell culture and transient expression
• Previous experience with molecular cloning techniques (primer design, PCR, gel extraction, restriction/homology cloning), sequence confirmation, and plasmid preparation
• Previous experience with protein purification (protein A/G affinity, IMAC, size exclusion, ion exchange chromatography) and protein characterization methods, including SDS-PAGE/cGE, aSEC, mass spec, endotoxin measurement.

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.

Pfizer Bio Medicine Design group at San Diego, CA is seeking an outstanding and highly motivated Associate Scientist with training in protein biochemistry to join a dynamic team in antibody discovery, optimization, and production. This role requires good understanding and hands-on skills in protein/antibody production and engineering.

Work Location Assignment:
On Premise

The annual base salary for this position ranges from $60,200.00 to $97,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives. Benefits include a 401(k) plan with Pfizer Matching Contributions,…