Director, Computational Safety Assessment

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

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Our Single Altos Value:
Everyone Owns Achieving Our Inspiring Mission
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We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.

An exciting opportunity is available for a talented Director to join the Institute of Medicine (IOM) Development Sciences team at Altos Labs. We are seeking a very highly motivated, curious, and collaborative Individual Contributor, who is passionate and dedicated to employing their expertise to restore cell health and resilience and reverse disease. This position will be part of a multidisciplinary team within the IOM to develop novel therapeutic projects and pipelines at Altos.

You will work in a highly dynamic and cross‑functional environment and bring a demonstrable track record of strong safety experience to drive data analysis and become an active participant of drug de‑risking during discovery and translational research from target discovery to development.

• Provide strategic leadership in defining and implementing the computational biology strategy within IOM, in alignment with broader computational innovation goals at Altos Labs.
• Provide long‑term vision and oversee cross‑functional integration with Research, Clinical Pharmacology, Safety, and IT.
• This role will be supported by and provide matrix leadership, as an Individual Contributor, to a team, comprising in‑house expertise and specialized external partners.
• Collaborate closely with Discovery Sciences, Computational Biology, Functional Genomics, Chemistry and Proteomic colleagues across Altos to share expertise, best practices and data analysis to support projects and goals.
• Lead the design and analysis of functional gene editing screens and multi‑omics datasets such as DNA sequencing, Transcriptomics and Epigenomics.
• Lead biomarker initiatives through the integrative analysis of internal and external genomic/genetic data.
• Support target discovery and translational research through the development of methods to interrogate large OMICs data sets.
• Build and maintain computational pipelines for the integrative analysis and visualization of Genomics and Proteomics data to support target liability assessment and guide clinical monitoring strategies.
• Oversee data infrastructure and computational environment to ensure robust data management.
• Communicate data analysis and scientific strategy effectively to internal stakeholders and external partners.
• Support development of new approach methodologies (NAMs) and computational methods to achieve 3
  
  Rs in drug development.
• Understand specific business needs and translate the scientific and regulatory challenges and opportunities into smarter data innovation solutions, and drive validation strategies for model performance.
• Drive rollout, re‑enforcement, monitoring, and continuous improvement of implemented data science initiatives.
• Mentor and provide training on the use and utility of predictive ML approaches in drug safety and submissions.

• Demonstrable history of translating computational innovation, e.g., AI/ML methods, predictive modeling, multi‑omics data analysis, and effective use of public/commercial data sources into tangible decisions and impacts in drug portfolio projects.
• Strong track record of initiating, building, and scaling ideas across different functions and teams.
• Proven ability to deliver scalable, high‑impact insights and tools that shape decision‑making.
• Ability to stay current with scientific literature on targets and associated safety signals of interest and emerging computational methodologies, applying it to our work and driving…