Principal Scientist- (Protein Immunotherapy

About Us

Cali
-Skaggs Institute for Innovative Medicines, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Cali
-Skaggs was founded on the principle that the creation of new medicines can be accelerated by pairing world‑class biomedical research with state‑of‑the‑art drug discovery and development capabilities. Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists.

Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Cali
-Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re‑investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Cali
-Skaggs’ drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age‑related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.

Principal Scientist (Protein Immunotherapy)

Cali  is seeking a talented Principal Research Scientist in the area of Protein Immunotherapy. This position will work as part of an interdisciplinary team to translate innovative protein therapies for the treatment of inflammation, autoimmunity and cancer, moving programs from ideation into first‑in‑human clinical trials. Specifically, projects will be focused on the development of next generation multi‑specific antibodies to control complex immune cell pathways in cancer and inflammatory diseases.

While working within the scope of these projects, this position will also have the unique opportunity to explore novel ideas within the scope of the broader portfolio, from aging to infectious disease. Cali ’s open lab space design and collaborative environment encourage the seamless flow of ideas within and between research groups. This position will receive hands on training in translational research and gain knowledge on how scientific ideas are translated into drugs to help patients in need.

The ideal candidate is expected to bring the basic scientific proficiencies listed below at the start. This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within the Cali  family. This position will require training and managing entry level Research Associates, with increased responsibility over time.

• Design and execute project plans focused on comprehensive immune profiling using flow cytometry, including signaling pathway characterization, xenograft‑derived cell processing, and functional assays such as cytotoxicity, proliferation, activation, and survival assays.
• Perform cell biology workflows involving the isolation, characterization, and assay development of primary human and murine cells, immune and tumor cell lines relevant to immuno‑oncology research, and primary patient‑derived cells.
• Design, develop, and characterize antibody‑based therapeutics, including bi‑specific and multi‑specific antibodies.
• Apply automation technologies to support high‑throughput antibody screening in primary cell‑based assays.
• Conduct gene editing of primary human immune cells using advanced platforms such as CRISPR, TALEN, and other endonuclease technologies, utilizing diverse delivery methods including protein and mRNA electroporation as well as viral vector systems.
• Effectively manage a team of PhD trained scientists to deliver on goals.
• Prepare reports and present experimental findings during regular team and project meetings.

• Bachelor’s degree in Biology, Chemical Biology, Biochemistry, or a related…