Senior Scientist, Medicinal Chemistry

Position Summary

We are seeking a talented medicinal chemist with excellent communication and collaboration skills and demonstrated experience working collaboratively in multi-disciplinary teams (spanning chemistry, biology, pharmacology, DMPK and toxicology). The successful candidate will lead from the lab and be a key driver of medicinal chemistry strategy and a critical contributor to projects, (with opportunities for project leadership), from inception through clinical candidate nomination.

Applicants should be well versed in drug design concepts and have demonstrated individual and team impact on small molecule Hit to Lead and Lead Optimization efforts.

Collaborate with a senior Project Lead to formulate medicinal chemistry strategy and then independently manage the execution of this strategy including overseeing the internal and external chemistry teams. Projects in scope for this role will typically initiate at the transition from hit validation into hit to lead and progress to Development Candidate (DC) nomination.

• Contribute intellectually to chemistry project teams through data analysis, compound designs to address key multiparametric optimization challenges in addition to synthetic troubleshooting and optimization
• Leading from the bench – candidate will spend a portion of their time in the lab enabling and impacting project progression by developing challenging chemistry that can be transferred to external partners
• Manage external chemistry CRO resources
• Selects compounds for progression through the assay flowchart
• Work within mandated laboratory safety policies and maintain an electronic notebook to company standards.
• Contribute to patent filings, publications and presentations
• Collaborate with other line functions (biology, pharmacology, biochemistry, DMPK, etc) to design key experiments and to set project goals and strategies.
• Present project updates to key stakeholders including chemistry and company leadership

• PhD in organic chemistry, or related field with 5+ years, MS with 8+ years or BS with 11+ years of relevant experience
• High level of creativity and productivity with strong synthetic problem-solving skills, synthetic methods and reactions mechanisms are required.
• Demonstrated expertise in modern methods and technologies in synthetic organic chemistry
• Demonstrated expertise in drug design to improve compound affinity, drug-likeness and DMPK/safety properties
• Familiarity with structure and ligand based drug design concepts
• Excellent communication skills
• Collaborative mindset

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard)

We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of…