Scientist - Synthetic Chemistry

About Satomic

Satomic’s mission is to close the gap from idea to molecule with faster navigation of chemical space. We are building an automated chemistry platform that integrates laboratory robotics, software, and AI to transform small-molecule synthesis and drug discovery.

This role is critical to Satomic’s mission by developing the chemistries that open valuable chemical space for exploration with reliability, speed, and scale on our automated platform. This work directly expands the possibilities our partners can explore in solving the most important challenges in drug discovery and human health.

This is an individual contributor role developing synthetic chemistry workflows that expand what Satomic’s automated chemical synthesis platform can reliably make. You will design and execute experiments to pressure test workflows for high-throughput automated synthesis and turn compelling reactions into robust, platform-ready methods that expand our reach into chemical space.

An exceptional candidate has a rock solid foundation in synthetic organic chemistry and a bias towards thoughtful experiment design to probe assumptions in the field. You will design and optimize reactions, interpret analytical results and decide the next experiments needed to improve scope, performance, and reliability. You will collaborate with Platform and ML colleagues to ensure reaction development workflows produce experimental data that is structured, traceable, and reproducible for downstream applications.

This is a lab-based position for a chemist who takes pride in rigorous experimental execution, learns quickly, and is motivated to build chemistry workflows that are robust, scalable, and innovative.

By 30 Days, You Will Have

• Learned to independently operate core laboratory workflows, instrumentation, and software.
• Generated decision-quality data for one project that contributes to workflow improvements for production chemistry challenges.
• Proposed an experimental plan for testing chemical method robustness at scale.

By 90 Days, You Will Have

• Delivered at least one optimized workflow based on experiments you designed and executed with clear before-and-after performance data (yield, throughput, purity, stability, coverage, etc.).
• Improved at least one tool, method, or workflow in collaboration with the Platform team.
• Delivered at least 4 automated reaction condition sets for addition to our predictive models that will expand Satomic’s accessible chemical space.

By 1 Year, You Will Have

• Developed and optimized at least 10 automated reaction condition sets supporting platform expansion.
• Independently proposed and executed next-step experiments for 75% of assigned projects and workflows without requiring detailed direction.
• Identified and implemented at least 2 improvements to laboratory workflows, condition optimization approaches, or data methods which are adopted by the wider team.

By 5 Years, You Will Have

• Become a subject matter expert in multiple reaction classes, synthetic workflows, and platform features.
• Expanded Satomic’s reaction roadmap by identifying and developing high-value reaction classes that unlock broader chemical space, simpler routes, or faster molecule delivery.
• Established reaction development practices that consistently produce platform-ready methods with high-quality data, clear substrate coverage, and reliable performance.
• Become a recognized technical leader within Satomic, mentoring exceptional junior chemists and shaping how the company tackles new chemistry.

• Design, execute, and optimize synthetic routes and chemical reactions.
• Analyze and interpret analytical data to guide experimental decisions, including LCMS, NMR, and other data types.
• Improve chemical methods and workflows to support automated synthesis needs.
• Stay current with emerging trends and innovations in synthetic and medicinal chemistry to identify high-value reaction classes to expand Satomic’s accessible chemical space.
• Collaborate with cross-functional teams to execute on multidisciplinary initiatives including machine learning, laboratory automation, and software development.
• Ensure proper…