Senior Scientist -II, Conjugation

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Full Time Scientist San Diego, CA, San Diego, CA, US

30+ days ago Requisition

Salary Range: $ To $ Annually

We are seeking a highly motivated and qualified individual to join our Conjugation-Discovery Chemistry Department as a Senior Scientist I and work as part of a team to drive success. Ideal candidates will be self-motivated, independent, committed to the generation of high-quality data within a fast-paced and innovative research team. The Senior Scientist I will support ongoing RNA-based drug discovery projects in several therapeutic areas.

• Design, synthesis, purification and analysis of oligonucleotide-conjugates on antibodies and other modalities. Develop and optimize conjugation protocols using novel chemistries and technologies for target drug delivery.
• Evaluate SAR on the conjugates and drive the program by collaborating cross-functionally with the teams.
• Track progress against project timelines, generate regular status updates, and communicate progress to the team.
• Carry out assigned laboratory functions applying knowledge and skill in an accurate, timely manner.
• Establish and maintain excellent working relationships with critical collaborative partners throughout the company to advance discovery research activities to pre-clinical development.
• Contribute to the preparation of research reports and presentations for internal project teams, leadership team, and external audience.
• Manage and maintain equipment, reagents and dedicated laboratory environment needed to carry out assignments.
• Maintain updated and well-organized lab notebooks and batch records.
• Execute daily laboratory operations with an approach designed to minimize risks and hazard waste streams.
• Maintain all appropriate corporate standards for facility safety and hazardous material management.
• Other duties as assigned.

Reasonable accommodation(s) may be made to enable qualified individuals with disabilities to perform the essential functions of a job, on a case-by-case basis.

Physical presence at the ADARx Pharmaceuticals worksite is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

• Ph.D. in Chemistry, or related scientific discipline
• 3-5 years bioconjugation-related industrial experience.
• Understanding of project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.
• Strong problem-solving skills and a proactive attitude towards exploring new approaches.
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management teams are essential for this role.
• In-depth knowledge of modern bioconjugation methods on antibodies (ADC, AOC), proteins, peptides, and other biomolecules.
• Hands-on experience in the analytical characterization of the conjugates with strong analytical mindset. Proficiency in purification techniques such as RP-HPLC, FPLC, SEC, and IEX.
• Proficiency working with Microsoft Office Suite Products.

• Previous experience with RNA/oligonucleotide therapeutics is preferred but not essential.
• A track-record of impacting drug discovery programs through driving projects to key decision points.
• In-depth knowledge of modern organic synthetic methods, purification and analytical techniques as well as medicinal chemistry.

• Positive attitude and high personal and ethical standards. A strong team player with a passion for science and drug discovery.
• Must be able to work independently as well in cross-functional team settings with supervision as needed.
• Adaptable / Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges with confidence and professionalism.
• Self-motivated with excellent interpersonal, organizational and communication skills with the ability to take a hands-on approach to work effectively in a dynamic and collaborative, fast-paced environment.

• This is a full-time position, Monday-Friday, occasional overtime.
• Pay is commensurate with experience.
• Equity-based compensation
• Performance-based bonuses
• 401(k) with Company Match
• Flexible Spending Account
• Life Insurance
• Employee Assistance Program
• Employee Discounts
• Paid Vacation
• Paid Holidays
• Paid Sick, Jury Duty, Bereavement

• United States (Required)
• As a condition of employment, you must successfully complete all post-offer, pre-employment requirements, including but not limited to a background check.

ADARx Pharmaceuticals, Inc., (the "Company" or "ADARx") located in San Diego, is a clinical stage biotechnology company committed to…