Principal Scientist, Structural Biology

Job Title

Principal Scientist – Structural Biology (onsite, San Diego, CA)

At Novartis, the Protein Sciences group plays a pivotal role in advancing early‑stage drug discovery by enabling deep structural and functional insights into therapeutic targets. Structural Biology is a cornerstone capability, enabling structure‑guided drug discovery for some of the most challenging and high‑impact targets in medicine. This is a unique opportunity to join a world‑class structural biology team within one of the largest and most innovative pharmaceutical companies, with access to state‑of‑the‑art instrumentation and a collaborative environment that empowers meaningful contributions to the discovery and development of life‑changing medicines.

• Lead and execute protein production and X‑ray crystallography to elucidate protein‑small molecule, protein‑peptide, and/or protein‑protein interactions, supporting drug discovery initiatives.
• Successfully drive gene‑to‑structure small molecule drug discovery projects.
• Leverage expertise in protein production and structural biology to characterize structure‑function relationships, investigate novel mechanisms of action, and address complex scientific questions.
• Collaborate with cross‑functional teams, including protein scientists, biophysicists, chemists, and computational modelers, to facilitate structure‑based drug design.
• Advance initiatives and drug discovery programs by leveraging innovative approaches, such as AI applications.

• Ph.D. in structural biology, biophysics, biochemistry, or a related field with over 5 years of relevant experience in X‑ray crystallography within either industrial or academic settings.
• Demonstrated expertise in protein expression across
  
  E. coli, insect, and mammalian expression systems, and extensive experience in protein purification and characterization.
• Proven track record in application of X‑ray crystallography to characterize protein‑ligand and protein‑protein complexes, including crystallization screening, optimization, data processing, structure refinement, and analysis.
• Outstanding communication skills and strong ability to collaborate within multidisciplinary teams in a fast‑paced, goal‑driven environment.

• Understanding of AI/ML tools for structural biology.
• Experience with biochemical assays and biophysical methods.
• Experience with Cryo‑EM is a plus.

Salary ranges:
Principal Scientist I: $108,500 – $201,500 per year
Principal Scientist II: $119,700 – $222,300 per year

Final salary offered is determined based on factors such as relevant skills and experience. The offer will be reviewed periodically. The compensation package includes a performance‑based cash incentive and, depending on the level of the role, eligibility for annual equity awards. US‑based employees receive a comprehensive benefits package covering health, life and disability benefits, a 401(k) with company contribution and match, and a generous time‑off package that includes vacation, personal days, holidays and other leaves.